U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MLO6 Seven transmembrane MLO family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842450, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MLO6
    Official Full Name
    Seven transmembrane MLO family protein
    Primary source
    TAIR:AT1G61560
    Locus tag
    AT1G61560
    See related
    Araport:AT1G61560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMLO6; MILDEW RESISTANCE LOCUS O 6; T25B24.9; T25B24_9
    Summary
    A member of a large family of seven-transmembrane domain proteins specific to plants, homologs of the barley mildew resistance locus o (MLO) protein. The Arabidopsis genome contains 15 genes encoding MLO proteins, with localization in plasma membrane. Phylogenetic analysis revealed four clades of closely-related AtMLO genes. ATMLO6 belongs to the clade IV, with AtMLO2, AtMLO3 and AtMLO12. The gene is expressed during early seedling growth, in roots and lateral root primordia, in flower and fruit abscission zone, in vascular system of cotyledons, young leaves and petals, in mature rosette leaves, in anthers, as shown by GUS activity patterns. The expression of several phylogenetically closely-related AtMLO genes showed similar or overlapping tissue specificity and analogous responsiveness to external stimuli, suggesting functional redundancy, co-function, or antagonistic function(s).
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MLO6 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Sequence:
    Chromosome: 1; NC_003070.9 (22708468..22712289, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene miscRNA Neighboring gene S-locus lectin protein kinase family protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ralf-like 8 Neighboring gene ralf-like 9

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The powdery mildew-resistant Arabidopsis mlo2 mlo6 mlo12 triple mutant displays altered infection phenotypes with diverse types of phytopathogens. Acevedo-Garcia J, et al. Sci Rep, 2017 Aug 24. PMID 28839137, Free PMC Article
    2. Expression analysis of the AtMLO gene family encoding plant-specific seven-transmembrane domain proteins. Chen Z, et al. Plant Mol Biol, 2006 Mar. PMID 16525893
    3. Conserved requirement for a plant host cell protein in powdery mildew pathogenesis. Consonni C, et al. Nat Genet, 2006 Jun. PMID 16732289
    4. Identification of ubiquitinated proteins in Arabidopsis. Manzano C, et al. Plant Mol Biol, 2008 Sep. PMID 18535787
    5. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_001333984.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Seven transmembrane MLO family protein
    NP_001185281.1
    • MILDEW RESISTANCE LOCUS O 6 (MLO6); CONTAINS InterPro DOMAIN/s: Mlo-related protein (InterPro:IPR004326); BEST Arabidopsis thaliana protein match is: Seven transmembrane MLO family protein (TAIR:AT1G11310.1).
    NP_001185283.1
    • MILDEW RESISTANCE LOCUS O 6 (MLO6); CONTAINS InterPro DOMAIN/s: Mlo-related protein (InterPro:IPR004326); BEST Arabidopsis thaliana protein match is: Seven transmembrane MLO family protein (TAIR:AT1G11310.1).
    NP_001319285.1
    • MILDEW RESISTANCE LOCUS O 6 (MLO6); CONTAINS InterPro DOMAIN/s: Mlo-related protein (InterPro:IPR004326); BEST Arabidopsis thaliana protein match is: Seven transmembrane MLO family protein (TAIR:AT1G11310.1).
    NP_176350.1
    • MILDEW RESISTANCE LOCUS O 6 (MLO6); FUNCTIONS IN: calmodulin binding; INVOLVED IN: defense response to fungus, incompatible interaction, cell death, defense response; LOCATED IN: plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Mlo-related protein (InterPro:IPR004326); BEST Arabidopsis thaliana protein match is: Seven transmembrane MLO family protein (TAIR:AT1G11310.1); Has 556 Blast hits to 535 proteins in 58 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 551; Viruses - 0; Other Eukaryotes - 5 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      22708468..22712289 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104836.2 → NP_176350.1  Seven transmembrane MLO family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176350.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94KB7, Q9SY94
      UniProtKB/TrEMBL
      A0A5S9WNM2, A0A654ELJ7
      Conserved Domains (1) summary
      pfam03094
      Location:11 → 495
      Mlo; Mlo family

    2. NM_001333987.1 → NP_001322616.1  Seven transmembrane MLO family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WGM1, A0A1P8AUH2

    3. NM_001333988.1 → NP_001322614.1  Seven transmembrane MLO family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WER6, A0A1P8AUK5

    4. NM_001333986.1 → NP_001322615.1  Seven transmembrane MLO family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WER6, A0A1P8AUK5

    5. NM_001333985.1 → NP_001322617.1  Seven transmembrane MLO family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WER6, A0A1P8AUK5

    6. NM_001333983.1 → NP_001322619.1  Seven transmembrane MLO family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WGM1, A0A1P8AUI9

    7. NM_001333989.1 → NP_001322618.1  Seven transmembrane MLO family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WGM1, A0A1P8AUH2

    8. NM_001198352.1 → NP_001185281.1  Seven transmembrane MLO family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185281.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WNM2, A0A654ELJ7, F4HVC3
      Conserved Domains (1) summary
      pfam03094
      Location:1 → 433
      Mlo; Mlo family

    9. NM_001198354.1 → NP_001185283.1  Seven transmembrane MLO family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185283.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WNM2, A0A654ELJ7, F4HVC3
      Conserved Domains (1) summary
      pfam03094
      Location:1 → 433
      Mlo; Mlo family

    10. NM_001333984.1 → NP_001319285.1  Seven transmembrane MLO family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WNM2, A0A654ELJ7, F4HVC5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94KB7.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.