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    CCR1 cinnamoyl coa reductase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838165, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CCR1
    Official Full Name
    cinnamoyl coa reductase 1
    Primary source
    TAIR:AT1G15950
    Locus tag
    AT1G15950
    See related
    Araport:AT1G15950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCCR1; CINNAMOYL COA REDUCTASE; cinnamoyl coa reductase 1; IRREGULAR XYLEM 4; IRX4; T24D18.5; T24D18_5
    Summary
    Encodes a cinnamoyl CoA reductase. Involved in lignin biosynthesis.
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    Genomic context

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    See CCR1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Sequence:
    Chromosome: 1; NC_003070.9 (5478603..5482180)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein Neighboring gene Tudor/PWWP/MBT superfamily protein Neighboring gene ncRNA Neighboring gene NRAMP metal ion transporter 6 Neighboring gene DNA glycosylase superfamily protein Neighboring gene NDH-dependent cyclic electron flow 1 Neighboring gene cyclic nucleotide gated channel 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CCR1, an enzyme required for lignin biosynthesis in Arabidopsis, mediates cell proliferation exit for leaf development. Xue J, et al. Plant J, 2015 Aug. PMID 26058952
    2. Redirection of the phenylpropanoid pathway to feruloyl malate in Arabidopsis mutants deficient for cinnamoyl-CoA reductase 1. Mir Derikvand M, et al. Planta, 2008 Apr. PMID 18046574
    3. The Arabidopsis cinnamoyl CoA reductase irx4 mutant has a delayed but coherent (normal) program of lignification. Laskar DD, et al. Plant J, 2006 Dec. PMID 17092316
    4. Kinetic and inhibition studies of cinnamoyl-CoA reductase 1 from Arabidopsis thaliana. Baltas M, et al. Plant Physiol Biochem, 2005 Aug. PMID 16122934
    5. Two cinnamoyl-CoA reductase (CCR) genes from Arabidopsis thaliana are differentially expressed during development and in response to infection with pathogenic bacteria. Lauvergeat V, et al. Phytochemistry, 2001 Aug. PMID 11430991

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the product of the CINNAMOYL CoA REDUCTASE (CCR1) gene, which is required for lignin biosynthesis, participates in the process of cell proliferation exit in leaves.
      Title: CCR1, an enzyme required for lignin biosynthesis in Arabidopsis, mediates cell proliferation exit for leaf development.
    2. Repressing both the CAD and the CCR activities results in sterility and dwarfism.
      Title: The simultaneous repression of CCR and CAD, two enzymes of the lignin biosynthetic pathway, results in sterility and dwarfism in Arabidopsis thaliana.
    3. Mutants deficient for cinnamoyl-CoA reductase 1 have three to four-times less sinapoyl malate (SM) than controls and accumulate some feruloyl malate.
      Title: Redirection of the phenylpropanoid pathway to feruloyl malate in Arabidopsis mutants deficient for cinnamoyl-CoA reductase 1.
    4. A study evaluating lignin formation in IRX4 mutated A. thaliana is reported.
      Title: The Arabidopsis cinnamoyl CoA reductase irx4 mutant has a delayed but coherent (normal) program of lignification.
    5. The purification of the recombinant AtCCR1 protein expressed in E. coli and the subsequent determination of its kinetic properties towards its main substrates and the inhibitory effect of 5 substrate analogs are reported.
      Title: Kinetic and inhibition studies of cinnamoyl-CoA reductase 1 from Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001084075.1
    NM_001332191.1
    NM_001332192.1
    NM_001332193.1
    NM_001332194.1
    NM_001332195.1
    NM_101463.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cinnamoyl-CoA reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within lignin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cinnamoyl coa reductase 1
    NP_001077544.1
    • cinnamoyl coa reductase 1 (CCR1); CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: cinnamoyl coa reductase (TAIR:AT1G80820.1); Has 11995 Blast hits to 11983 proteins in 1896 species: Archae - 218; Bacteria - 5371; Metazoa - 416; Fungi - 931; Plants - 2539; Viruses - 54; Other Eukaryotes - 2466 (source: NCBI BLink).
    NP_001319013.1
    • cinnamoyl coa reductase 1 (CCR1); CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: cinnamoyl coa reductase (TAIR:AT1G80820.1); Has 12077 Blast hits to 12065 proteins in 1900 species: Archae - 220; Bacteria - 5385; Metazoa - 413; Fungi - 986; Plants - 2545; Viruses - 54; Other Eukaryotes - 2474 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      5478603..5482180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001332191.1 → NP_001319013.1  cinnamoyl coa reductase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FPM0, Q9S9N9
      UniProtKB/TrEMBL
      A0A178W9D8, A0A5S9UPF4, A0A7G2DVR6
      Conserved Domains (1) summary
      PLN02214
      Location:1 → 344
      PLN02214; cinnamoyl-CoA reductase

    2. NM_001084075.1 → NP_001077544.1  cinnamoyl coa reductase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077544.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8MQW5, C0Z2K0
      Conserved Domains (2) summary
      PLN02214
      Location:1 → 337
      PLN02214; cinnamoyl-CoA reductase
      PLN00198
      Location:6 → 311
      PLN00198; anthocyanidin reductase; Provisional

    3. NM_101463.4 → NP_173047.1  cinnamoyl coa reductase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173047.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FPM0, Q9S9N9
      UniProtKB/TrEMBL
      A0A178W9D8, A0A5S9UPF4, A0A7G2DVR6
      Conserved Domains (1) summary
      PLN02214
      Location:1 → 344
      PLN02214; cinnamoyl-CoA reductase

    4. NM_001332192.1 → NP_001322095.1  cinnamoyl coa reductase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AT30, C0Z2K0

    5. NM_001332193.1 → NP_001322096.1  cinnamoyl coa reductase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ASX3, C0Z2K0

    6. NM_001332194.1 → NP_001322097.1  cinnamoyl coa reductase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ASX8, C0Z2K0

    7. NM_001332195.1 → NP_001322098.1  cinnamoyl coa reductase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ASX1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S9N9.1

    Gene LinkOut

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