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    GRX480 Thioredoxin superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839748, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GRX480
    Official Full Name
    Thioredoxin superfamily protein
    Primary source
    TAIR:AT1G28480
    Locus tag
    AT1G28480
    See related
    Araport:AT1G28480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    roxy19; ROXY19
    Summary
    Encodes GRX480, a member of the glutaredoxin family that regulates protein redox state. GRX480 interacts with TGA factors and suppresses JA-responsive PDF1.2 transcription. GRX480 transcription is SA-inducible and requires NPR1. Maybe involved in SA/JA cross-talk.
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    Genomic context

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    See GRX480 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_003070.9 (10013434..10014256, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene NAC domain containing protein 10 Neighboring gene ncRNA Neighboring gene syntaxin of plants 61 Neighboring gene hypothetical protein (DUF626)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ectopically expressed glutaredoxin ROXY19 negatively regulates the detoxification pathway in Arabidopsis thaliana. Huang LJ, et al. BMC Plant Biol, 2016 Sep 13. PMID 27624344, Free PMC Article
    2. SA-inducible Arabidopsis glutaredoxin interacts with TGA factors and suppresses JA-responsive PDF1.2 transcription. Ndamukong I, et al. Plant J, 2007 Apr. PMID 17397508
    3. Repression of the Arabidopsis thaliana jasmonic acid/ethylene-induced defense pathway by TGA-interacting glutaredoxins depends on their C-terminal ALWL motif. Zander M, et al. Mol Plant, 2012 Jul. PMID 22207719
    4. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
    5. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ROXY19 functions as negative regulators of TGA-dependent promoters controlling detoxification genes.
      Title: Ectopically expressed glutaredoxin ROXY19 negatively regulates the detoxification pathway in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_102616.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within jasmonic acid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salicylic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within salicylic acid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Thioredoxin superfamily protein
    NP_174170.1
    • GRX480; FUNCTIONS IN: electron carrier activity, protein disulfide oxidoreductase activity; INVOLVED IN: salicylic acid mediated signaling pathway, jasmonic acid mediated signaling pathway, response to salicylic acid stimulus; LOCATED IN: cellular_component unknown; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Glutaredoxin-like, plant II (InterPro:IPR011905), Thioredoxin fold (InterPro:IPR012335), Glutaredoxin (InterPro:IPR002109), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: Glutaredoxin family protein (TAIR:AT1G03850.2); Has 774 Blast hits to 772 proteins in 85 species: Archae - 0; Bacteria - 6; Metazoa - 52; Fungi - 18; Plants - 684; Viruses - 0; Other Eukaryotes - 14 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      10013434..10014256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102616.2 → NP_174170.1  Thioredoxin superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174170.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C1JGQ9, Q9SGP6
      UniProtKB/TrEMBL
      A0A178W584, A0A5S9W7A5
      Conserved Domains (1) summary
      TIGR02189
      Location:35 → 137
      GlrX-like_plant; Glutaredoxin-like family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SGP6.1

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