FBR12 Eukaryotic translation initiation factor 5A-1 (eIF-5A 1) protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: FBR12
Official Full Name: Eukaryotic translation initiation factor 5A-1 (eIF-5A 1) protein
Primary source: TAIR:AT1G26630
Locus tag: AT1G26630
See related: Araport:AT1G26630
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATELF5A-2; ELF5A-2; EUKARYOTIC ELONGATION FACTOR 5A-2; FUMONISIN B1-RESISTANT12; T24P13.1; T24P13_1
Summary: Eukaryotic translation initiation factor 5A-2. Involved in programmed cell death triggered as a response to pseudomonas syringae infection. Loss of function mutants are more resistant to infection.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See FBR12 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 5

Sequence:: Chromosome: 1; NC_003070.9 (9205800..9207417)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FBR12/eIF5A-2 is involved in cytokinin signaling to directly regulate root protoxylem specification
Title: The Arabidopsis eukaryotic translation initiation factor eIF5A-2 regulates root protoxylem development by modulating cytokinin signaling.
Crystal structure of Arabidopsis translation initiation factor eIF-5A2
Title: Crystal structure of Arabidopsis translation initiation factor eIF-5A2.
key element of the signal transduction pathway resulting in plant programmed cell death
Title: Eukaryotic translation initiation factor 5A is involved in pathogen-induced cell death and development of disease symptoms in Arabidopsis.
fundamental for plant growth and development by regulating cell division, cell growth, and cell death
Title: Functional characterization of the Arabidopsis eukaryotic translation initiation factor 5A-2 that plays a crucial role in plant growth and development by regulating cell division, cell growth, and cell death.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_001084128.1

Supported by ESTs:

NM_102425.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translational elongation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translational termination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to wounding	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within symbiont-induced defense-related programmed cell death	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
NOT located_in Golgi apparatus	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

Go to the top of the page Help

Preferred Names: Eukaryotic translation initiation factor 5A-1 (eIF-5A 1) protein

NP_001077597.1

FUMONISIN B1-RESISTANT12 (FBR12); FUNCTIONS IN: translation initiation factor activity; INVOLVED IN: translational initiation, defense response to bacterium, response to wounding, programmed cell death; LOCATED IN: nucleus; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold (InterPro:IPR012340), Translation elongation factor, IF5A, hypusine site (InterPro:IPR019769), Translation protein SH3-like, subgroup (InterPro:IPR014722), Translation elongation factor, IF5A (InterPro:IPR001884), Translation elongation factor, IF5A C-terminal (InterPro:IPR020189), Translation protein SH3-like (InterPro:IPR008991), Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), KOW (InterPro:IPR005824); BEST Arabidopsis thaliana protein match is: eukaryotic elongation factor 5A-3 (TAIR:AT1G69410.1); Has 1298 Blast hits to 1297 proteins in 403 species: Archae - 255; Bacteria - 0; Metazoa - 362; Fungi - 216; Plants - 256; Viruses - 0; Other Eukaryotes - 209 (source: NCBI BLink).

NP_173985.1

FUMONISIN B1-RESISTANT12 (FBR12); FUNCTIONS IN: translation initiation factor activity; INVOLVED IN: in 7 processes; LOCATED IN: nucleus; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold (InterPro:IPR012340), Translation elongation factor, IF5A, hypusine site (InterPro:IPR019769), Translation protein SH3-like, subgroup (InterPro:IPR014722), Translation elongation factor, IF5A (InterPro:IPR001884), Translation elongation factor, IF5A C-terminal (InterPro:IPR020189), Translation protein SH3-like (InterPro:IPR008991), Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), KOW (InterPro:IPR005824); BEST Arabidopsis thaliana protein match is: eukaryotic elongation factor 5A-3 (TAIR:AT1G69410.1); Has 1331 Blast hits to 1330 proteins in 409 species: Archae - 256; Bacteria - 0; Metazoa - 365; Fungi - 242; Plants - 261; Viruses - 0; Other Eukaryotes - 207 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

9205800..9207417

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_102425.4 → NP_173985.1 Eukaryotic translation initiation factor 5A-1 (eIF-5A 1) protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_173985.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4HPA2, Q547G3, Q93VP3, Q9LQY9

UniProtKB/TrEMBL

A0A178WC68, A0A5S9W0W8, A0A7G2DWR9

Conserved Domains (1) summary

PLN03107
Location:1 → 157

PLN03107; eukaryotic translation initiation factor 5A; Provisional
NM_001084128.1 → NP_001077597.1 Eukaryotic translation initiation factor 5A-1 (eIF-5A 1) protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001077597.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q93VP3

Conserved Domains (3) summary

PLN03107
Location:1 → 137

PLN03107; eukaryotic translation initiation factor 5A; Provisional

pfam01287
Location:84 → 120

eIF-5a; Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold

pfam08207
Location:22 → 53

EFP_N; Elongation factor P (EF-P) KOW-like domain