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    MOM ATP-dependent helicase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837322, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MOM
    Official Full Name
    ATP-dependent helicase family protein
    Primary source
    TAIR:AT1G08060
    Locus tag
    AT1G08060
    See related
    Araport:AT1G08060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MAINTENANCE OF METHYLATION; MOM1; MORPHEUS MOLECULE; MORPHEUS MOLECULE 1; T6D22.14; T6D22_14
    Summary
    Encodes a transcriptional silencer.
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    Genomic context

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    See MOM in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    16
    Sequence:
    Chromosome: 1; NC_003070.9 (2501704..2511084, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene trimethylguanosine synthase (DUF707) Neighboring gene Zinc finger (C3HC4-type RING finger) family protein Neighboring gene alpha carbonic anhydrase 5 Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1. Nishimura T, et al. PLoS Genet, 2012 Feb. PMID 22346760, Free PMC Article
    2. Disruption of the plant gene MOM releases transcriptional silencing of methylated genes. Amedeo P, et al. Nature, 2000 May 11. PMID 10821279
    3. Divergent evolution of CHD3 proteins resulted in MOM1 refining epigenetic control in vascular plants. Caikovski M, et al. PLoS Genet, 2008 Aug 22. PMID 18725928, Free PMC Article
    4. MOM1 and Pol-IV/V interactions regulate the intensity and specificity of transcriptional gene silencing. Yokthongwattana C, et al. EMBO J, 2010 Jan 20. PMID 19910926, Free PMC Article
    5. Expression, crystallization and preliminary X-ray diffraction analysis of the CMM2 region of the Arabidopsis thaliana Morpheus' molecule 1 protein. Petty TJ, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Aug 1. PMID 20693667, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Canonical transcriptional gene silencing may contribute to long-term heat response and recovery through MOM1.
      Title: Canonical transcriptional gene silencing may contribute to long-term heat response and recovery through MOM1.
    2. The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation.
      Title: The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation.
    3. The SUMO interaction motif responsible for the interaction of MOM1 with SUMO.
      Title: Exploring potential roles for the interaction of MOM1 with SUMO and the SUMO E3 ligase-like protein PIAL2 in transcriptional silencing.
    4. study suggests that PIAL1 and PIAl2 act as components of the MOM1-containing complex to mediate transcriptional silencing at heterochromatin regions.
      Title: The SUMO E3 Ligase-Like Proteins PIAL1 and PIAL2 Interact with MOM1 and Form a Novel Complex Required for Transcriptional Silencing.
    5. Data indicate function of DNA methylation1 (DDM1) and Morpheus' Molecule1 (MOM1) in rapid resetting of stress induced epigenetic states, and therefore also in preventing their mitotic propagation and transgenerational inheritance.
      Title: Identification of genes preventing transgenerational transmission of stress-induced epigenetic states.
    6. synergistic transcriptional regulation in the mom1/atmorc6 double mutant, indicating that these epigenetic regulators act mainly in different silencing pathways, both independently of DNA methylation
      Title: Transcriptional gene silencing by Arabidopsis microrchidia homologues involves the formation of heteromers.
    7. These results reveal a surprising separation of epigenetic activities that enable the single, large MOM1 protein to coordinate cooperating mechanisms of epigenetic regulation
      Title: Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1.
    8. the degree of contribution of MOM1 to maintenance of the silent states varies in different loci, and other silencing machineries, including those in the RNA-directed DNA methylation pathway, interact genetically with MOM1
      Title: Epigenetic silencing of endogenous repetitive sequences by MORPHEUS' MOLECULE1 in Arabidopsis thaliana.
    9. MOM1 plays a role in preventing aberrant RNA transcriptional read-through.
      Title: MORPHEUS' MOLECULE1 is required to prevent aberrant RNA transcriptional read-through in Arabidopsis.
    10. Crystals of Morpheus' molecule 1 belonged to the trigonal space group P3(1)21 (or P3(2)21), with unit-cell parameters a=85.64, c=292.74 A. Structure determination is ongoing
      Title: Expression, crystallization and preliminary X-ray diffraction analysis of the CMM2 region of the Arabidopsis thaliana Morpheus' molecule 1 protein.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001331755.1
    NM_100680.4
    NM_179277.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables SUMO binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of gene expression, epigenetic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression, epigenetic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene silencing by regulatory ncRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent helicase family protein
    NP_563806.1
    • MORPHEUS MOLECULE (MOM); INVOLVED IN: chromatin silencing; LOCATED IN: nucleus; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 7 growth stages; BEST Arabidopsis thaliana protein match is: chromatin remodeling 4 (TAIR:AT5G44800.1); Has 8505 Blast hits to 7857 proteins in 726 species: Archae - 6; Bacteria - 999; Metazoa - 3217; Fungi - 2019; Plants - 785; Viruses - 95; Other Eukaryotes - 1384 (source: NCBI BLink).
    NP_849608.1
    • MORPHEUS MOLECULE (MOM); INVOLVED IN: chromatin silencing; LOCATED IN: nucleus; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 7 growth stages; BEST Arabidopsis thaliana protein match is: chromatin remodeling 4 (TAIR:AT5G44800.1); Has 8505 Blast hits to 7857 proteins in 726 species: Archae - 6; Bacteria - 999; Metazoa - 3217; Fungi - 2019; Plants - 785; Viruses - 95; Other Eukaryotes - 1384 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2501704..2511084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100680.4 → NP_563806.1  ATP-dependent helicase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563806.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GXZ0, Q9LN02, Q9M658, Q9M659
      UniProtKB/TrEMBL
      A0A5S9T7U8
      Conserved Domains (1) summary
      pfam06752
      Location:1830 → 1993
      E_Pc_C; Enhancer of Polycomb C-terminus

    2. NM_001331755.1 → NP_001322007.1  ATP-dependent helicase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ASM1, A0A5S9T7U8

    3. NM_179277.1 → NP_849608.1  ATP-dependent helicase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849608.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GXZ0, Q9LN02, Q9M658, Q9M659
      UniProtKB/TrEMBL
      A0A5S9T7U8
      Conserved Domains (1) summary
      pfam06752
      Location:1830 → 1993
      E_Pc_C; Enhancer of Polycomb C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M658.1

    Gene LinkOut

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