U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SOT18 desulfo-glucosinolate sulfotransferase 18 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843749, updated on 14-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SOT18
    Official Full Name
    desulfo-glucosinolate sulfotransferase 18
    Primary source
    TAIR:AT1G74090
    Locus tag
    AT1G74090
    See related
    Araport:AT1G74090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS SULFOTRANSFERASE 5B; ATSOT18; ATST5B; desulfo-glucosinolate sulfotransferase 18; DESULFO-GLUCOSINOLATE SULFOTRANSFERASE 18; F2P9.4; F2P9_4
    Summary
    encodes a desulfoglucosinolate sulfotransferase, involved in the final step of glucosinolate core structure biosynthesis. Has a broad-substrate specificity with preference with methionine-derived desulfoglucosinolates.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SOT18 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_003070.9 (27862814..27864193)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein Neighboring gene myb domain protein 122 Neighboring gene galacturonosyltransferase Neighboring gene sulfotransferase 16 Neighboring gene cytochrome P450, family 78, subfamily A, polypeptide 10

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Structural and biochemical studies of sulphotransferase 18 from Arabidopsis thaliana explain its substrate specificity and reaction mechanism. Hirschmann F, et al. Sci Rep, 2017 Jun 23. PMID 28646214, Free PMC Article
    2. Kinetics and substrate specificities of desulfo-glucosinolate sulfotransferases in Arabidopsis thaliana. Klein M, et al. Physiol Plant, 2009 Feb. PMID 19077143
    3. Desulfoglucosinolate sulfotransferases from Arabidopsis thaliana catalyze the final step in the biosynthesis of the glucosinolate core structure. Piotrowski M, et al. J Biol Chem, 2004 Dec 3. PMID 15358770
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The structure of AtSOT18 invigorates the similarity between plant and mammalian sulphotransferases, which illustrates the evolutionary conservation of this multifunctional enzyme family.
      Title: Structural and biochemical studies of sulphotransferase 18 from Arabidopsis thaliana explain its substrate specificity and reaction mechanism.
    2. AtSOT18 preferred the long-chain ds-Gl, 7-methylthioheptyl and 8-methylthiooctyl, derived from methionine.
      Title: Kinetics and substrate specificities of desulfo-glucosinolate sulfotransferases in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    NM_106069.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables aliphatic desulfoglucosinolate sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aromatic desulfoglucosinolate sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within glucosinolate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    desulfo-glucosinolate sulfotransferase 18
    NP_177549.1
    • desulfo-glucosinolate sulfotransferase 18 (SOT18); FUNCTIONS IN: in 8 functions; INVOLVED IN: glucosinolate biosynthetic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Sulfotransferase domain (InterPro:IPR000863); BEST Arabidopsis thaliana protein match is: sulfotransferase 17 (TAIR:AT1G18590.1); Has 2716 Blast hits to 2675 proteins in 177 species: Archae - 0; Bacteria - 191; Metazoa - 1688; Fungi - 1; Plants - 535; Viruses - 0; Other Eukaryotes - 301 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      27862814..27864193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106069.3 → NP_177549.1  desulfo-glucosinolate sulfotransferase 18 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177549.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LA18, Q9C9C9
      UniProtKB/TrEMBL
      A0A654ENT6, A0A7G2E8T4, T1P4S7, T1P4U2, T1P4V4, T1P4W7
      Conserved Domains (1) summary
      PLN02164
      Location:18 → 350
      PLN02164; sulfotransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C9C9.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools