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    APK3 adenosine-5'-phosphosulfate (APS) kinase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821077, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APK3
    Official Full Name
    adenosine-5'-phosphosulfate (APS) kinase 3
    Primary source
    TAIR:AT3G03900
    Locus tag
    AT3G03900
    See related
    Araport:AT3G03900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    adenosine-5'-phosphosulfate (APS) kinase 3; F20H23.5; F20H23_5
    Summary
    Provides activated sulfate for the sulfation of secondary metabolites, including the glucosinolates. Redundant with APK4.
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    Genomic context

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    See APK3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (1002765..1005025, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene sterol O-acyltransferase, putative (DUF1639) Neighboring gene FMN binding protein Neighboring gene ncRNA Neighboring gene glutamate dehydrogenase 3 Neighboring gene H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adenosine-5'-phosphosulfate kinase is essential for Arabidopsis viability. Mugford SG, et al. FEBS Lett, 2010 Jan 4. PMID 19903478
    2. Disruption of adenosine-5'-phosphosulfate kinase in Arabidopsis reduces levels of sulfated secondary metabolites. Mugford SG, et al. Plant Cell, 2009 Mar. PMID 19304933, Free PMC Article
    3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001337491.1
    NM_001337492.1
    NM_001337493.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables adenylylsulfate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylylsulfate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in hydrogen sulfide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within male gamete generation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sulfate assimilation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenosine-5'-phosphosulfate (APS) kinase 3
    NP_001319463.1
    • adenosine-5'-phosphosulfate (APS) kinase 3 (APK3); FUNCTIONS IN: transferase activity, transferring phosphorus-containing groups, kinase activity, ATP binding; INVOLVED IN: male gamete generation, sulfate assimilation; LOCATED IN: cytosol; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Adenylylsulphate kinase, C-terminal (InterPro:IPR002891); BEST Arabidopsis thaliana protein match is: APS kinase (TAIR:AT2G14750.1); Has 5006 Blast hits to 5006 proteins in 1478 species: Archae - 56; Bacteria - 2976; Metazoa - 240; Fungi - 284; Plants - 130; Viruses - 2; Other Eukaryotes - 1318 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1002765..1005025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001337491.1 → NP_001319463.1  adenosine-5'-phosphosulfate (APS) kinase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SQR9, Q9SRW7
      UniProtKB/TrEMBL
      A0A178V945, A0A5S9X982
      Conserved Domains (1) summary
      COG0529
      Location:8 → 206
      CysC; Adenylylsulfate kinase or related kinase [Inorganic ion transport and metabolism]

    2. NM_001337492.1 → NP_001327493.1  adenosine-5'-phosphosulfate (APS) kinase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SQR9, Q9SRW7
      UniProtKB/TrEMBL
      A0A178V945, A0A5S9X982
      Conserved Domains (1) summary
      COG0529
      Location:8 → 206
      CysC; Adenylylsulfate kinase or related kinase [Inorganic ion transport and metabolism]

    3. NM_001337493.1 → NP_001327494.1  adenosine-5'-phosphosulfate (APS) kinase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LSH7
      Conserved Domains (1) summary
      cl17190
      Location:8 → 131
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SRW7.1

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