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    MDHAR monodehydroascorbate reductase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820155, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MDHAR
    Official Full Name
    monodehydroascorbate reductase
    Primary source
    TAIR:AT3G09940
    Locus tag
    AT3G09940
    See related
    Araport:AT3G09940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA MONODEHYDROASCORBATE REDUCTASE 3; AtMDAR3; ATMDAR3; F8A24.20; MDAR2; MDAR3; monodehydroascorbate reductase; MONODEHYDROASCORBATE REDUCTASE 2; MONODEHYDROASCORBATE REDUCTASE 3
    Summary
    Encodes a member of the monodehydroascorbate reductase gene family. Critical for a mutualistic symbiosis between the host Arabidopsis and the root colonizing fungus Piriformospora indica.
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    Genomic context

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    See MDHAR in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (3056375..3059244, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Pollen Ole e 1 allergen and extensin family protein Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein Neighboring gene uncharacterized protein Neighboring gene Calcineurin-like metallo-phosphoesterase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Monodehydroascorbate reductase 2 and dehydroascorbate reductase 5 are crucial for a mutualistic interaction between Piriformospora indica and Arabidopsis. Vadassery J, et al. J Plant Physiol, 2009 Aug 15. PMID 19386380
    2. Arabidopsis peroxisomes possess functionally redundant membrane and matrix isoforms of monodehydroascorbate reductase. Lisenbee CS, et al. Plant J, 2005 Sep. PMID 16146528
    3. Coordinated activation of metabolic pathways for antioxidants and defence compounds by jasmonates and their roles in stress tolerance in Arabidopsis. Sasaki-Sekimoto Y, et al. Plant J, 2005 Nov. PMID 16262714
    4. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    5. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MDAR2 and DHAR5 are crucial for producing sufficient ascorbate to maintain the interaction between Piriformospora indica and Arabidopsis in a mutualistic state. [MDAR2]
      Title: Monodehydroascorbate reductase 2 and dehydroascorbate reductase 5 are crucial for a mutualistic interaction between Piriformospora indica and Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001125135.1
    NM_111829.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monodehydroascorbate reductase (NADH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of biological process involved in symbiotic interaction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to jasmonic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to symbiotic fungus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    monodehydroascorbate reductase
    NP_001118607.1
    • monodehydroascorbate reductase (MDHAR); FUNCTIONS IN: monodehydroascorbate reductase (NADH) activity; INVOLVED IN: response to jasmonic acid stimulus, regulation of symbiosis, encompassing mutualism through parasitism, response to water deprivation, response to salt stress, response to symbiotic fungus; LOCATED IN: cytosol; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: Pyridine nucleotide-disulphide oxidoreductase family protein (TAIR:AT5G03630.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_566361.1
    • monodehydroascorbate reductase (MDHAR); FUNCTIONS IN: monodehydroascorbate reductase (NADH) activity; INVOLVED IN: response to jasmonic acid stimulus, regulation of symbiosis, encompassing mutualism through parasitism, response to water deprivation, response to salt stress, response to symbiotic fungus; LOCATED IN: cytosol; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: Pyridine nucleotide-disulphide oxidoreductase family protein (TAIR:AT5G03630.1); Has 31567 Blast hits to 31505 proteins in 3041 species: Archae - 687; Bacteria - 24961; Metazoa - 895; Fungi - 665; Plants - 718; Viruses - 0; Other Eukaryotes - 3641 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3056375..3059244 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111829.4 → NP_566361.1  monodehydroascorbate reductase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566361.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SR59
      UniProtKB/TrEMBL
      A0A178V9L8, A0A5S9XAK8, A0A654F7B0
      Conserved Domains (1) summary
      pfam07992
      Location:31 → 324
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    2. NM_001125135.1 → NP_001118607.1  monodehydroascorbate reductase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118607.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V9L8, B3H5M0
      Conserved Domains (3) summary
      pfam00070
      Location:159 → 241
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam07992
      Location:33 → 316
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      cl21454
      Location:213 → 278
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SR59.1

    Gene LinkOut

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