FOLB1 Dihydroneopterin aldolase [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: FOLB1
Official Full Name: Dihydroneopterin aldolase
Primary source: TAIR:AT3G11750
Locus tag: AT3G11750
See related: Araport:AT3G11750
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Summary: Encodes an enzyme that can act as a aldolase or an epimerase for 7,8-dihydroneopterin and 7,8-dihydromonapterin in vitro. It is likely to act in tetrahydrofolate biosynthesis in vivo.
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Genomic context

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See FOLB1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 3

Sequence:: Chromosome: 3; NC_003074.8 (3714762..3716018, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_112008.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables dihydroneopterin aldolase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in tetrahydrofolate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Dihydroneopterin aldolase

NP_187781.1

FOLB1; FUNCTIONS IN: dihydroneopterin aldolase activity; INVOLVED IN: folic acid and derivative metabolic process; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Dihydroneopterin aldolase (InterPro:IPR006157), Dihydroneopterin aldolase subgroup (InterPro:IPR006156); BEST Arabidopsis thaliana protein match is: Dihydroneopterin aldolase (TAIR:AT5G62980.1); Has 3723 Blast hits to 3723 proteins in 1537 species: Archae - 4; Bacteria - 2961; Metazoa - 0; Fungi - 2; Plants - 88; Viruses - 0; Other Eukaryotes - 668 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

3714762..3716018 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_112008.2 → NP_187781.1 Dihydroneopterin aldolase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_187781.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A2RVT4, Q6R8J1, Q9SF23

UniProtKB/TrEMBL

A0A178V8H2, A0A5S9XB55, A0A654F665

Conserved Domains (1) summary

cd00534
Location:22 → 139

DHNA_DHNTPE; Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and ...