IPP2 isopentenyl pyrophosphate:dimethylallyl pyrophosphate isomerase 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: IPP2
Official Full Name: isopentenyl pyrophosphate:dimethylallyl pyrophosphate isomerase 2
Primary source: TAIR:AT3G02780
Locus tag: AT3G02780
See related: Araport:AT3G02780
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATISOPENTENYL DIPHOSPHE ISOMERASE 2; F13E7.28; F13E7_28; IDI2; IPIAT1; isopentenyl pyrophosphate:dimethylallyl pyrophosphate isomerase 2; ISOPENTENYL PYROPHOSPHATE:DIMETHYLLALLYL PYROPHOSPHATE ISOMERASE
Summary: Encodes a protein with isopentenyl diphosphate:dimethylallyl diphosphate isomerase activity. There is genetic evidence that it functions in the mevalonate, but not the MEP biosynthetic pathway.
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Genomic context

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See IPP2 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 6

Sequence:: Chromosome: 3; NC_003074.8 (602401..605506, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Each of Arabidopsis IPP2 and IPP1 isomerases is found in multiple but partially overlapping subcellular locations, and each can compensate for the loss of the other through partial redundancy in the cytosol.
Title: The Arabidopsis thaliana type I Isopentenyl Diphosphate Isomerases are targeted to multiple subcellular compartments and have overlapping functions in isoprenoid biosynthesis.
IPI plays a critical role in isoprenoid biosynthesis via the MVA pathway, and IPI is essential for the maintenance of appropriate levels of IPP and DMAPP in different subcellular compartments in plants. [IPI2]
Title: Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001337434.1

Supported by ESTs:

NM_111146.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables isopentenyl-diphosphate delta-isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables isopentenyl-diphosphate delta-isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chlorophyll biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chlorophyll biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in dimethylallyl diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within flower development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within isoprenoid biosynthetic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: isopentenyl pyrophosphate:dimethylallyl pyrophosphate isomerase 2

NP_186927.1

isopentenyl pyrophosphate:dimethylallyl pyrophosphate isomerase 2 (IPP2); FUNCTIONS IN: isopentenyl-diphosphate delta-isomerase activity; INVOLVED IN: chlorophyll biosynthetic process, flower development, isoprenoid biosynthetic process; LOCATED IN: cytosol, mitochondrion, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NUDIX hydrolase domain-like (InterPro:IPR015797), NUDIX hydrolase domain (InterPro:IPR000086), Isopentenyl-diphosphate delta-isomerase, type 1 (InterPro:IPR011876); BEST Arabidopsis thaliana protein match is: isopentenyl diphosphate isomerase 1 (TAIR:AT5G16440.1); Has 2187 Blast hits to 2186 proteins in 784 species: Archae - 35; Bacteria - 1163; Metazoa - 210; Fungi - 137; Plants - 180; Viruses - 0; Other Eukaryotes - 462 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

602401..605506 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_111146.4 → NP_186927.1 isopentenyl pyrophosphate:dimethylallyl pyrophosphate isomerase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_186927.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q42553

UniProtKB/TrEMBL

A0A178V9S3, A0A5S9X8V2, A0A654F526

Conserved Domains (1) summary

PLN02552
Location:50 → 284

PLN02552; isopentenyl-diphosphate delta-isomerase
NM_001337434.1 → NP_001325698.1 isopentenyl pyrophosphate:dimethylallyl pyrophosphate isomerase 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I9LM15, A0A7G2EFB6