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    ATCAD4 GroES-like zinc-binding alcohol dehydrogenase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821479, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATCAD4
    Official Full Name
    GroES-like zinc-binding alcohol dehydrogenase family protein
    Primary source
    TAIR:AT3G19450
    Locus tag
    AT3G19450
    See related
    Araport:AT3G19450
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CAD; CAD-C; CAD4; CINNAMYL ALCOHOL DEHYDROGENASE 4
    Summary
    Encodes a catalytically active cinnamyl alcohol dehydrogenase which uses p-coumaryl aldehyde as a preferred substrate. It can also use caffeyl, coniferyl and d-hydroxyconiferyl aldehydes as substrates.
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    Genomic context

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    See ATCAD4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (6744377..6747238)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene late embryogenesis abundant protein-related / LEA protein-like protein Neighboring gene Pseudouridine synthase family protein Neighboring gene Reticulon family protein Neighboring gene F-box and associated interaction domains-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genomic nucleotide sequence of an Arabidopsis thaliana gene encoding a cinnamyl alcohol dehydrogenase. Baucher M, et al. Plant Physiol, 1995 Jan. PMID 7870825, Free PMC Article
    2. Manipulation of Guaiacyl and Syringyl Monomer Biosynthesis in an Arabidopsis Cinnamyl Alcohol Dehydrogenase Mutant Results in Atypical Lignin Biosynthesis and Modified Cell Wall Structure. Anderson NA, et al. Plant Cell, 2015 Aug. PMID 26265762, Free PMC Article
    3. Crystal structures and catalytic mechanism of the Arabidopsis cinnamyl alcohol dehydrogenases AtCAD5 and AtCAD4. Youn B, et al. Org Biomol Chem, 2006 May 7. PMID 16633561
    4. CINNAMYL ALCOHOL DEHYDROGENASE-C and -D are the primary genes involved in lignin biosynthesis in the floral stem of Arabidopsis. Sibout R, et al. Plant Cell, 2005 Jul. PMID 15937231, Free PMC Article
    5. Expression pattern of two paralogs encoding cinnamyl alcohol dehydrogenases in Arabidopsis. Isolation and characterization of the corresponding mutants. Sibout R, et al. Plant Physiol, 2003 Jun. PMID 12805615, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that disruption of the genes encoding both cinnamyl alcohol dehydrogenases CADC (At3g19450) and CADD (At4g34230) results in the atypical incorporation of hydroxycinnamaldehydes into lignin.
      Title: Manipulation of Guaiacyl and Syringyl Monomer Biosynthesis in an Arabidopsis Cinnamyl Alcohol Dehydrogenase Mutant Results in Atypical Lignin Biosynthesis and Modified Cell Wall Structure.
    2. Repressing both the CAD and the CCR activities results in sterility and dwarfism.
      Title: The simultaneous repression of CCR and CAD, two enzymes of the lignin biosynthetic pathway, results in sterility and dwarfism in Arabidopsis thaliana.
    3. determined the crystal structures of AtCAD5 in the apo-form and as a binary complex with NADP+, respectively, and modeled that of AtCAD4. The substrate-binding pockets of both AtCAD5 and AtCAD4 were also examined.
      Title: Crystal structures and catalytic mechanism of the Arabidopsis cinnamyl alcohol dehydrogenases AtCAD5 and AtCAD4.
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    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_112832.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cinnamyl-alcohol dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cinnamyl-alcohol dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cinnamyl-alcohol dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lignin biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lignin biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    GroES-like zinc-binding alcohol dehydrogenase family protein
    NP_188576.1
    • ATCAD4; CONTAINS InterPro DOMAIN/s: GroES-like (InterPro:IPR011032), Alcohol dehydrogenase GroES-like (InterPro:IPR013154), Alcohol dehydrogenase, zinc-containing, conserved site (InterPro:IPR002328), Alcohol dehydrogenase, C-terminal (InterPro:IPR013149), Alcohol dehydrogenase superfamily, zinc-containing (InterPro:IPR002085); BEST Arabidopsis thaliana protein match is: cinnamyl alcohol dehydrogenase 5 (TAIR:AT4G34230.1); Has 40533 Blast hits to 40509 proteins in 3018 species: Archae - 756; Bacteria - 27152; Metazoa - 1406; Fungi - 3053; Plants - 2651; Viruses - 3; Other Eukaryotes - 5512 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      6744377..6747238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112832.4 → NP_188576.1  GroES-like zinc-binding alcohol dehydrogenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188576.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B1GUX6, P48523, Q53ZN1, Q8L9U1, Q94B56
      UniProtKB/TrEMBL
      A0A178VK12, A0A5S9XDN0, A0A654F8P9
      Conserved Domains (1) summary
      PLN02514
      Location:1 → 358
      PLN02514; cinnamyl-alcohol dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48523.1

    Gene LinkOut

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