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    NDA1 alternative NAD(P)H dehydrogenase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837229, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NDA1
    Official Full Name
    alternative NAD(P)H dehydrogenase 1
    Primary source
    TAIR:AT1G07180
    Locus tag
    AT1G07180
    See related
    Araport:AT1G07180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    alternative NAD(P)H dehydrogenase 1; alternative NAD(P)H dehydrogenase 1; ARABIDOPSIS THALIANA INTERNAL NON-PHOSPHORYLATING NAD ( P ) H DEHYDROGENASE; ATNDI1; F10K1.11; F10K1_11; NADH-DEHYDROGENASE
    Summary
    Internal NAD(P)H dehydrogenase in mitochondria. The predicted protein sequence has high homology with other designated NAD(P)H DHs from microorganisms; the capacity for matrix NAD(P)H oxidation via the rotenone-insensitive pathway is significantly reduced in the Atndi1 mutant plant line; the in vitro translation product of AtNDI1 is imported into isolated mitochondria and located on the inside of the inner membrane.
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    Genomic context

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    See NDA1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (2204104..2207099)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene PHF5-like protein Neighboring gene alternative NAD(P)H dehydrogenase Neighboring gene Lon protease Neighboring gene Double Clp-N motif-containing P-loop nucleoside triphosphate hydrolases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Light regulation of the Arabidopsis respiratory chain. Multiple discrete photoreceptor responses contribute to induction of type II NAD(P)H dehydrogenase genes. Escobar MA, et al. Plant Physiol, 2004 Sep. PMID 15333756, Free PMC Article
    2. Identification of AtNDI1, an internal non-phosphorylating NAD(P)H dehydrogenase in Arabidopsis mitochondria. Moore CS, et al. Plant Physiol, 2003 Dec. PMID 14630960, Free PMC Article
    3. Mitochondrial alternative NADH dehydrogenases NDA1 and NDA2 promote survival of reoxygenation stress in Arabidopsis by safeguarding photosynthesis and limiting ROS generation. Jethva J, et al. New Phytol, 2023 Apr. PMID 36464787
    4. Suppression of NDA-type alternative mitochondrial NAD(P)H dehydrogenases in arabidopsis thaliana modifies growth and metabolism, but not high light stimulation of mitochondrial electron transport. Wallström SV, et al. Plant Cell Physiol, 2014 May. PMID 24486764, Free PMC Article
    5. Type II NAD(P)H dehydrogenases are targeted to mitochondria and chloroplasts or peroxisomes in Arabidopsis thaliana. Carrie C, et al. FEBS Lett, 2008 Sep 3. PMID 18703057

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mitochondrial alternative NADH dehydrogenases NDA1 and NDA2 promote survival of reoxygenation stress in Arabidopsis by safeguarding photosynthesis and limiting ROS generation.
      Title: Mitochondrial alternative NADH dehydrogenases NDA1 and NDA2 promote survival of reoxygenation stress in Arabidopsis by safeguarding photosynthesis and limiting ROS generation.
    2. Data indicate that suppressing the type II NAD(P)H dehydrogenase genes NDA1 (BT005564.1) and NDA2. (NM_128553.2) substantially reduced levels of both proteins in leaf mitochondria.
      Title: Suppression of NDA-type alternative mitochondrial NAD(P)H dehydrogenases in arabidopsis thaliana modifies growth and metabolism, but not high light stimulation of mitochondrial electron transport.
    Submit: New GeneRIF Correction

    General gene information

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    NM_100592.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NADH dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables NADPH dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADH oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alternative NAD(P)H dehydrogenase 1
    NP_563783.1
    • alternative NAD(P)H dehydrogenase 1 (NDA1); FUNCTIONS IN: NADH dehydrogenase activity; INVOLVED IN: oxidation reduction; LOCATED IN: intrinsic to mitochondrial inner membrane, mitochondrion; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: alternative NAD(P)H dehydrogenase 2 (TAIR:AT2G29990.1); Has 9792 Blast hits to 9601 proteins in 2135 species: Archae - 248; Bacteria - 7524; Metazoa - 53; Fungi - 647; Plants - 379; Viruses - 0; Other Eukaryotes - 941 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2204104..2207099
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100592.5 → NP_563783.1  alternative NAD(P)H dehydrogenase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563783.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GWA1, Q8L5V3, Q9LML0
      UniProtKB/TrEMBL
      A0A5S9T2H6, A0A654E7H2
      Conserved Domains (1) summary
      PTZ00318
      Location:67 → 510
      PTZ00318; NADH dehydrogenase-like protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GWA1.1

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