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    CARB carbamoyl phosphate synthetase B [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839868, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CARB
    Official Full Name
    carbamoyl phosphate synthetase B
    Primary source
    TAIR:AT1G29900
    Locus tag
    AT1G29900
    See related
    Araport:AT1G29900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    carbamoyl phosphate synthetase B; CARBAMOYL PHOSPHATE SYNTHETASE LARGE SUBUNIT; CELLULOSE SYNTHASE LIKE B6; CLSB6; F1N18.6; F1N18_6; VEN3; VENOSA 3
    Summary
    Encodes carbamoyl phosphate synthetase (CPS) large subunit (CARB), also named as VEN3. Heterologous expression of the Arabidopsis VEN3 and VEN6 genes in a CPS-deficient Escherichia coli strain fully restored bacterial growth in minimal medium, demonstrating the enzymatic activity of the VEN3 and VEN6 proteins.
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    Genomic context

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    See CARB in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (10467956..10472211)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene glycyl-tRNA synthetase / glycine-tRNA ligase Neighboring gene O-acetyltransferase family protein Neighboring gene chlorophyll A/B binding protein 3 Neighboring gene chlorophyll A/B-binding protein 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of ven3 and ven6 reticulate mutants reveals the importance of arginine biosynthesis in Arabidopsis leaf development. Mollá-Morales A, et al. Plant J, 2011 Feb. PMID 21265888
    2. The regulatory PII protein controls arginine biosynthesis in Arabidopsis. Ferrario-Méry S, et al. FEBS Lett, 2006 Apr 3. PMID 16545809
    3. Effects of phosphate limitation on expression of genes involved in pyrimidine synthesis and salvaging in Arabidopsis. Hewitt MM, et al. Plant Physiol Biochem, 2005 Feb. PMID 15820655
    4. The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Peltier JB, et al. Mol Cell Proteomics, 2006 Jan. PMID 16207701
    5. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    NM_102730.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-arginine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within L-arginine biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to phosphate starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of carbamoyl-phosphate synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    carbamoyl phosphate synthetase B
    NP_564338.1
    • carbamoyl phosphate synthetase B (CARB); FUNCTIONS IN: catalytic activity, ATP binding; INVOLVED IN: cellular response to phosphate starvation, arginine biosynthetic process; LOCATED IN: chloroplast stroma, chloroplast, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Carbamoyl phosphate synthase, large subunit, N-terminal (InterPro:IPR005481), Carbamoyl phosphate synthetase, large subunit, ATP-binding (InterPro:IPR005479), MGS-like (InterPro:IPR011607), PreATP-grasp-like fold (InterPro:IPR016185), Carbamoyl phosphate synthetase, large subunit, oligomerisation (InterPro:IPR005480), Carbamoyl phosphate synthase, large subunit, glutamine-dependent (InterPro:IPR006275), ATP-grasp fold (InterPro:IPR011761), ATP-grasp fold, subdomain 2 (InterPro:IPR013816), Carbamoyl phosphate synthase, large subunit (InterPro:IPR005483), Pre-ATP-grasp fold (InterPro:IPR013817); BEST Arabidopsis thaliana protein match is: acetyl-CoA carboxylase 2 (TAIR:AT1G36180.1); Has 49576 Blast hits to 29968 proteins in 5011 species: Archae - 665; Bacteria - 22536; Metazoa - 6475; Fungi - 1021; Plants - 476; Viruses - 0; Other Eukaryotes - 18403 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      10467956..10472211
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102730.2 → NP_564338.1  carbamoyl phosphate synthetase B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564338.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q42601
      UniProtKB/TrEMBL
      A0A178WB43, A0A5S9WFA7
      Conserved Domains (1) summary
      PLN02735
      Location:77 → 1177
      PLN02735; carbamoyl-phosphate synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q42601.1

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