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    LPLAT1 MBOAT (membrane bound O-acyl transferase) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837820, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LPLAT1
    Official Full Name
    MBOAT (membrane bound O-acyl transferase) family protein
    Primary source
    TAIR:AT1G12640
    Locus tag
    AT1G12640
    See related
    Araport:AT1G12640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtLPLAT1; LPCAT1; lysophosphatidylcholine acyltransferase 1; lysophospholipid acyltransferase 1; T12C24.17; T12C24_17
    Summary
    Encodes a lysophosphatidylcholine acyltransferase (LPCAT). Participates in the Lands cycle in developing seeds.
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    Genomic context

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    See LPLAT1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (4303280..4305907, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Integrase-type DNA-binding superfamily protein Neighboring gene rRNA biogenesis RRP36-like protein Neighboring gene thionin-like protein Neighboring gene thionin-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LPCAT1 controls phosphate homeostasis in a zinc-dependent manner. Kisko M, et al. Elife, 2018 Feb 17. PMID 29453864, Free PMC Article
    2. Plant acyl-CoA:lysophosphatidylcholine acyltransferases (LPCATs) have different specificities in their forward and reverse reactions. Lager I, et al. J Biol Chem, 2013 Dec 27. PMID 24189065, Free PMC Article
    3. Castor LPCAT and PDAT1A Act in Concert to Promote Transacylation of Hydroxy-Fatty Acid onto Triacylglycerol. Lunn D, et al. Plant Physiol, 2020 Oct. PMID 32737074, Free PMC Article
    4. Metabolic interactions between the Lands cycle and the Kennedy pathway of glycerolipid synthesis in Arabidopsis developing seeds. Wang L, et al. Plant Cell, 2012 Nov. PMID 23150634, Free PMC Article
    5. Acyl editing and headgroup exchange are the major mechanisms that direct polyunsaturated fatty acid flux into triacylglycerols. Bates PD, et al. Plant Physiol, 2012 Nov. PMID 22932756, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Castor LPCAT and PDAT1A Act in Concert to Promote Transacylation of Hydroxy-Fatty Acid onto Triacylglycerol.
      Title: Castor LPCAT and PDAT1A Act in Concert to Promote Transacylation of Hydroxy-Fatty Acid onto Triacylglycerol.
    2. Using genome-wide association studies, the authors first identified allelic variation of the Lyso-PhosphatidylCholine (PC) AcylTransferase 1 (LPCAT1) gene as the key determinant of shoot inorganic phosphate accumulation under zinc deficiency.
      Title: LPCAT1 controls phosphate homeostasis in a zinc-dependent manner.
    3. LPCAT1 and LPCAT2 enzymes catalyzed the acylation and de-acylation of both sn positions of PC, with a preference for the sn-2 position.
      Title: Plant acyl-CoA:lysophosphatidylcholine acyltransferases (LPCATs) have different specificities in their forward and reverse reactions.
    4. Arabidopsis thaliana LPCATs, LPCAT1 and LPCAT2, participate in the Lands cycle in developing seeds.
      Title: Metabolic interactions between the Lands cycle and the Kennedy pathway of glycerolipid synthesis in Arabidopsis developing seeds.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_101134.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 1-acylglycerophosphocholine O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysophospholipid acyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within galactolipid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within glycerolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phospholipid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within triglyceride biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in extracellular region HDA PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    MBOAT (membrane bound O-acyl transferase) family protein
    NP_172724.2
    • MBOAT (membrane bound O-acyl transferase) family protein; FUNCTIONS IN: acyltransferase activity; INVOLVED IN: biological_process unknown; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Membrane bound O-acyl transferase, MBOAT (InterPro:IPR004299); BEST Arabidopsis thaliana protein match is: MBOAT (membrane bound O-acyl transferase) family protein (TAIR:AT1G63050.1); Has 1204 Blast hits to 1199 proteins in 313 species: Archae - 0; Bacteria - 269; Metazoa - 625; Fungi - 142; Plants - 47; Viruses - 0; Other Eukaryotes - 121 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      4303280..4305907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101134.5 → NP_172724.2  MBOAT (membrane bound O-acyl transferase) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172724.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IDU4, Q8RWH4, Q9LN83
      UniProtKB/TrEMBL
      A0A7G2DWC0
      Conserved Domains (1) summary
      PLN02332
      Location:1 → 462
      PLN02332; membrane bound O-acyl transferase (MBOAT) family protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4IDU4.1

    Gene LinkOut

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