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    NPR4 NPR1-like protein 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827710, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NPR4
    Official Full Name
    NPR1-like protein 4
    Primary source
    TAIR:AT4G19660
    Locus tag
    AT4G19660
    See related
    Araport:AT4G19660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATNPR4; NPR1-like protein 4; T16H5.20; T16H5_20
    Summary
    Encodes NPR4, a ankyrin repeat BTB/POZ domain-containing protein with 36% sequence identity with NPR1. Mutants are more susceptible to the bacterial pathogen Pseudomonas syringe pv. tomato DC3000 and to the fungal pathogen Erysiphe cichoracearum, but do not differ markedly from wild type in interaction with virulent and avirulent strains of the oomycete Peronospora parasitica. NPR4 is required for basal defense against pathogens, and may be implicated in the cross-talk between the SA- and JA-dependent signaling pathways. NPR3 and NPR4 are receptors for the immune signal salicylic acid.
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    Genomic context

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    See NPR4 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Sequence:
    Chromosome: 4; NC_003075.7 (10696266..10698811, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Ras-related small GTP-binding family protein Neighboring gene TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing protein Neighboring gene Mitochondrial transcription termination factor family protein Neighboring gene RING/U-box superfamily protein Neighboring gene iron regulated transporter 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtNPR4 from Arabidopsis thaliana: expression, purification, crystallization and crystallographic analysis. Yang Q, et al. Acta Crystallogr F Struct Biol Commun, 2019 Jan 1. PMID 30605128, Free PMC Article
    2. Diverse Roles of the Salicylic Acid Receptors NPR1 and NPR3/NPR4 in Plant Immunity. Liu Y, et al. Plant Cell, 2020 Dec. PMID 33037144, Free PMC Article
    3. Salicylic Acid Regulates Pollen Tip Growth through an NPR3/NPR4-Independent Pathway. Rong D, et al. Mol Plant, 2016 Nov 7. PMID 27575693, Free PMC Article
    4. Structural basis of salicylic acid perception by Arabidopsis NPR proteins. Wang W, et al. Nature, 2020 Oct. PMID 32788727, Free PMC Article
    5. Opposite Roles of Salicylic Acid Receptors NPR1 and NPR3/NPR4 in Transcriptional Regulation of Plant Immunity. Ding Y, et al. Cell, 2018 May 31. PMID 29656896

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Diverse Roles of the Salicylic Acid Receptors NPR1 and NPR3/NPR4 in Plant Immunity.
      Title: Diverse Roles of the Salicylic Acid Receptors NPR1 and NPR3/NPR4 in Plant Immunity.
    2. Structural basis of salicylic acid perception by Arabidopsis NPR proteins.
      Title: Structural basis of salicylic acid perception by Arabidopsis NPR proteins.
    3. The expression, purification, crystallization and crystallographic analysis of Arabidopsis thaliana NPR4 protein have been reported.
      Title: AtNPR4 from Arabidopsis thaliana: expression, purification, crystallization and crystallographic analysis.
    4. both NPR1 and NPR3/NPR4 are bona fide salicylic acid receptors, but play opposite roles in transcriptional regulation of salicylic acid-induced defense gene expression
      Title: Opposite Roles of Salicylic Acid Receptors NPR1 and NPR3/NPR4 in Transcriptional Regulation of Plant Immunity.
    5. Salicylic Acid Regulates Pollen Tip Growth through an NPR3/NPR4-Independent Pathway
      Title: Salicylic Acid Regulates Pollen Tip Growth through an NPR3/NPR4-Independent Pathway.
    6. the NPR1 paralogues NPR3 and NPR4 are SA receptors that bind salicylic acid with different affinities
      Title: NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants.
    7. The role of NPR1, NPR3, and NPR4 in the disease resistance of A. thaliana are reported.
      Title: Negative regulation of defense responses in Arabidopsis by two NPR1 paralogs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001341366.1
    NM_118086.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables salicylic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables salicylic acid binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plant-type hypersensitive response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of jasmonic acid mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of jasmonic acid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of salicylic acid mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of salicylic acid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of systemic acquired resistance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to salicylic acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within systemic acquired resistance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in systemic acquired resistance, salicylic acid mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NPR1-like protein 4
    NP_193701.2
    • NPR1-like protein 4 (NPR4); CONTAINS InterPro DOMAIN/s: BTB/POZ (InterPro:IPR013069), NPR1/NIM1 like, C-terminal (InterPro:IPR021094), BTB/POZ fold (InterPro:IPR011333), Ankyrin repeat-containing domain (InterPro:IPR020683), BTB/POZ-like (InterPro:IPR000210), Ankyrin repeat (InterPro:IPR002110); BEST Arabidopsis thaliana protein match is: NPR1-like protein 3 (TAIR:AT5G45110.1); Has 1751 Blast hits to 1617 proteins in 183 species: Archae - 0; Bacteria - 140; Metazoa - 493; Fungi - 63; Plants - 647; Viruses - 2; Other Eukaryotes - 406 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      10696266..10698811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118086.3 → NP_193701.2  NPR1-like protein 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193701.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81848, Q5ICL9
      UniProtKB/TrEMBL
      A0A178UZK3
      Conserved Domains (7) summary
      pfam11900
      Location:215 → 258
      DUF3420; Domain of unknown function (DUF3420)
      smart00225
      Location:55 → 179
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd00204
      Location:260 → 352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12313
      Location:357 → 551
      NPR1_like_C; NPR1/NIM1 like defence protein C terminal
      pfam13857
      Location:302 → 355
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:284 → 313
      ANK; ANK repeat [structural motif]
      cl02518
      Location:42 → 133
      BTB; BTB/POZ domain

    2. NM_001341366.1 → NP_001328027.1  NPR1-like protein 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B3C8, A0A654FQW9
      Conserved Domains (7) summary
      pfam11900
      Location:215 → 258
      DUF3420; Domain of unknown function (DUF3420)
      smart00225
      Location:55 → 179
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd00204
      Location:260 → 352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12313
      Location:357 → 578
      NPR1_like_C; NPR1/NIM1 like defence protein C terminal
      pfam13857
      Location:302 → 355
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:284 → 313
      ANK; ANK repeat [structural motif]
      cl02518
      Location:42 → 133
      BTB; BTB/POZ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5ICL9.1

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