BAK1 BRI1-associated receptor kinase [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: BAK1
Official Full Name: BRI1-associated receptor kinase
Primary source: TAIR:AT4G33430
Locus tag: AT4G33430
See related: Araport:AT4G33430
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATBAK1; ATSERK3; BRI1-associated receptor kinase; ELG; ELONGATED; F17M5.190; F17M5_190; RECEPTOR KINASES LIKE SERK 10; RKS10; SERK3; SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE 3
Summary: Leu-rich receptor Serine/threonine protein kinase. Component of BR signaling that interacts with BRI1 in vitro and in vivo to form a heterodimer. Brassinolide-dependent association of BRI1 and BAK1 in vivo. Phosphorylation of both BRI1 and BAK1 on Thr residues was BR dependent. Although BAK1 and BRI1 alone localize in the plasma membrane, when BAK1 and BRI1 are coexpressed, the heterodimer BAK1/BRI1 they form is localized in the endosome.
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Genomic context

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See BAK1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 12

Sequence:: Chromosome: 4; NC_003075.7 (16086311..16090832, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association mechanism between Arabidopsis immune coreceptor BAK1 and Pseudomonas syringae effector HopF2.
Title: Association mechanism between Arabidopsis immune coreceptor BAK1 and Pseudomonas syringae effector HopF2.
Functional screening of the Arabidopsis 2C protein phosphatases family identifies PP2C15 as a negative regulator of plant immunity by targeting BRI1-associated receptor kinase 1.
Title: Functional screening of the Arabidopsis 2C protein phosphatases family identifies PP2C15 as a negative regulator of plant immunity by targeting BRI1-associated receptor kinase 1.
A pair of G-type lectin receptor-like kinases modulates nlp20-mediated immune responses by coupling to the RLP23 receptor complex.
Title: A pair of G-type lectin receptor-like kinases modulates nlp20-mediated immune responses by coupling to the RLP23 receptor complex.
Regulation of immune receptor kinase plasma membrane nanoscale organization by a plant peptide hormone and its receptors.
Title: Regulation of immune receptor kinase plasma membrane nanoscale organization by a plant peptide hormone and its receptors.
Infection of Arabidopsis by cucumber mosaic virus triggers jasmonate-dependent resistance to aphids that relies partly on the pattern-triggered immunity factor BAK1.
Title: Infection of Arabidopsis by cucumber mosaic virus triggers jasmonate-dependent resistance to aphids that relies partly on the pattern-triggered immunity factor BAK1.
Chemical control of receptor kinase signaling by rapamycin-induced dimerization.
Title: Chemical control of receptor kinase signaling by rapamycin-induced dimerization.
BAK1-induced RPK1 phosphorylation is essential for RPK1-mediated cell death in Arabidopsis.
Title: BAK1-induced RPK1 phosphorylation is essential for RPK1-mediated cell death in Arabidopsis.
Receptor-like protein kinases RPK1 and BAK1 sequentially form complexes with the cytoplasmic kinase OST1 to regulate ABA-induced stomatal closure.
Title: Receptor-like protein kinases RPK1 and BAK1 sequentially form complexes with the cytoplasmic kinase OST1 to regulate ABA-induced stomatal closure.
The root growth reduction in response to mechanical stress involves ethylene-mediated microtubule reorganization and transmembrane receptor-mediated signal transduction in Arabidopsis.
Title: The root growth reduction in response to mechanical stress involves ethylene-mediated microtubule reorganization and transmembrane receptor-mediated signal transduction in Arabidopsis.
The juxtamembrane domains of Arabidopsis CERK1, BAK1, and FLS2 play a conserved role in chitin-induced signaling.
Title: The juxtamembrane domains of Arabidopsis CERK1, BAK1, and FLS2 play a conserved role in chitin-induced signaling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001203975.1

Supported by ESTs:

NM_119497.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables receptor serine/threonine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brassinosteroid mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within brassinosteroid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to oomycetes	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plant ovule development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within plant-type hypersensitive response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: BRI1-associated receptor kinase

NP_001190904.1

BRI1-associated receptor kinase (BAK1); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Leucine-rich repeat (InterPro:IPR001611), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: somatic embryogenesis receptor-like kinase 4 (TAIR:AT2G13790.1).

NP_567920.1

BRI1-associated receptor kinase (BAK1); FUNCTIONS IN: protein binding, protein serine/threonine kinase activity, protein heterodimerization activity, kinase activity; INVOLVED IN: in 6 processes; LOCATED IN: endosome, plasma membrane, protein complex; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: somatic embryogenesis receptor-like kinase 4 (TAIR:AT2G13790.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

16086311..16090832 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001203975.1 → NP_001190904.1 BRI1-associated receptor kinase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190904.1

Status: REVIEWED

UniProtKB/TrEMBL

F4JIX9

Conserved Domains (4) summary

smart00219
Location:337 → 610

TyrKc; Tyrosine kinase, catalytic domain

cd14664
Location:342 → 613

STK_BAK1_like; Catalytic domain of the Serine/Threonine Kinase, BRI1 associated kinase 1 and related STKs

sd00033
Location:94 → 117

LRR_RI; leucine-rich repeat [structural motif]

pfam08263
Location:26 → 65

LRRNT_2; Leucine rich repeat N-terminal domain
NM_119497.5 → NP_567920.1 BRI1-associated receptor kinase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567920.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C0LGS0, Q94F62, Q9SZC0

UniProtKB/TrEMBL

A0A178UUK2, A0A5S9XZ41

Conserved Domains (3) summary

PLN00113
Location:8 → 181

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

cd14664
Location:295 → 566

STK_BAK1_like; Catalytic domain of the Serine/Threonine Kinase, BRI1 associated kinase 1 and related STKs

sd00033
Location:94 → 117

LRR_RI; leucine-rich repeat [structural motif]