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    HTA11 histone H2A 11 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824621, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HTA11
    Official Full Name
    histone H2A 11
    Primary source
    TAIR:AT3G54560
    Locus tag
    AT3G54560
    See related
    Araport:AT3G54560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    histone H2A 11
    Summary
    Encodes HTA11, a histone H2A protein. Loss of all H2A.Z (triple mutant with HTA8 and HTA9) results in a reduction in DNA methylation of transposons but not that of genes. Loss of H2A.Z causes misregulation of many genes involved in the response to developmental and environmental cues, and that these genes tend to have high levels of gene-body H2A.Z.
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    Genomic context

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    See HTA11 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Sequence:
    Chromosome: 3; NC_003074.8 (20196140..20197726)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene general control non-repressible 4 Neighboring gene DNA-directed RNA polymerase subunit beta-beta protein, putative (DUF506) Neighboring gene Plant calmodulin-binding protein-like protein Neighboring gene Proline-rich extensin-like family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HISTONE DEACETYLASE 9 stimulates auxin-dependent thermomorphogenesis in Arabidopsis thaliana by mediating H2A.Z depletion. van der Woude LC, et al. Proc Natl Acad Sci U S A, 2019 Dec 10. PMID 31767749, Free PMC Article
    2. Epigenetic regulation of anthocyanin biosynthesis by an antagonistic interaction between H2A.Z and H3K4me3. Cai H, et al. New Phytol, 2019 Jan. PMID 29959895
    3. Dual Role of the Histone Variant H2A.Z in Transcriptional Regulation of Stress-Response Genes. Sura W, et al. Plant Cell, 2017 Apr. PMID 28258158, Free PMC Article
    4. Arabidopsis SWR1-associated protein methyl-CpG-binding domain 9 is required for histone H2A.Z deposition. Potok ME, et al. Nat Commun, 2019 Jul 26. PMID 31350403, Free PMC Article
    5. The repressive role of Arabidopsis H2A.Z in transcriptional regulation depends on AtBMI1 activity. Gómez-Zambrano Á, et al. Nat Commun, 2019 Jun 27. PMID 31249301, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggests an antagonistic role between H2A.Z and H3K4me3 in the regulation of the expression of anthocyanin biosynthetic genes, highlighting a role of chromatin in gene regulation and reflecting the complexity of gene regulatory mechanisms.s [H2A.Z] [HTA11]
      Title: Epigenetic regulation of anthocyanin biosynthesis by an antagonistic interaction between H2A.Z and H3K4me3.
    2. YAF9A binds FLC chromatin and that YAF9 proteins regulate FLC expression by modulating the acetylation levels of H2A.Z and H4 but not H2A.Z deposition.[H2A.z]
      Title: Arabidopsis YAF9 histone readers modulate flowering time through NuA4-complex-dependent H4 and H2A.Z histone acetylation at FLC chromatin.
    3. MBD9 is a SWR1-C interacting protein required for H2A.Z deposition at a subset of actively transcribing genes. [H2A.Z]
      Title: Arabidopsis SWR1-associated protein methyl-CpG-binding domain 9 is required for histone H2A.Z deposition.
    4. HDA9 permits net eviction of the H2A.Z histone variant from nucleosomes associated with YUCCA8, allowing binding and transcriptional activation by PHYTOCHROME INTERACTING FACTOR 4, followed by auxin accumulation and thermomorphogenesis. [H2A.Z]
      Title: HISTONE DEACETYLASE 9 stimulates auxin-dependent thermomorphogenesis in Arabidopsis thaliana by mediating H2A.Z depletion.
    5. H2A.Z can be monoubiquitinated by the PRC1 components AtBMI1A/B/C. It is proposed that H2A.Z monoubiquitination plays a crucial role in transcriptional repression and, most probably, H2A.Z acetylation in transcriptional activation, while the different levels of H2A.Z along the genes may be a consequence of gene activity rather than an active mechanism to establish repression. [H2A.Z]
      Title: The repressive role of Arabidopsis H2A.Z in transcriptional regulation depends on AtBMI1 activity.
    6. Results show that H2A.Z-containing nucleosomes provide thermosensory information that is used to coordinate the ambient temperature transcriptome. [HTA11]
      Title: H2A.Z-containing nucleosomes mediate the thermosensory response in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001339683.1
    NM_115313.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within detection of temperature stimulus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within flower development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    histone H2A 11
    NP_191019.1
    • histone H2A 11 (HTA11); FUNCTIONS IN: DNA binding; INVOLVED IN: flower development, detection of temperature stimulus, defense response to bacterium; LOCATED IN: nucleus, nucleosome; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Histone H2A (InterPro:IPR002119), Histone-fold (InterPro:IPR009072), Histone core (InterPro:IPR007125); BEST Arabidopsis thaliana protein match is: histone H2A 8 (TAIR:AT2G38810.2); Has 3864 Blast hits to 3859 proteins in 326 species: Archae - 0; Bacteria - 0; Metazoa - 2525; Fungi - 296; Plants - 612; Viruses - 2; Other Eukaryotes - 429 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20196140..20197726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115313.5 → NP_191019.1  histone H2A 11 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191019.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23628
      UniProtKB/TrEMBL
      A0A178V944, A0A384KLN3, Q0WS87
      Conserved Domains (1) summary
      PLN00154
      Location:1 → 136
      PLN00154; histone H2A; Provisional

    2. NM_001339683.1 → NP_001325682.1  histone H2A 11 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23628
      UniProtKB/TrEMBL
      A0A178V944, A0A384KLN3, Q0WS87
      Conserved Domains (1) summary
      PLN00154
      Location:1 → 136
      PLN00154; histone H2A; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O23628.1

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