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    UVH1 Restriction endonuclease, type II-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834117, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UVH1
    Official Full Name
    Restriction endonuclease, type II-like superfamily protein
    Primary source
    TAIR:AT5G41150
    Locus tag
    AT5G41150
    See related
    Araport:AT5G41150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATRAD1; MEE6.22; MEE6_22; RAD1; REPAIR ENDONUCLEASE; ULTRAVIOLET HYPERSENSITIVE 1
    Summary
    Confers resistance to UV radiation. Homolog of the human xeroderma pigmentosum group F DNA repair and yeast Rad1 proteins
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    Genomic context

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    See UVH1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (16472764..16477417, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene meiosis chromosome segregation family protein Neighboring gene Esterase/lipase/thioesterase family protein Neighboring gene Esterase/lipase/thioesterase family protein Neighboring gene Myosin heavy chain-related protein Neighboring gene Pentatricopeptide repeat (PPR-like) superfamily protein Neighboring gene purine permease 12 Neighboring gene leucine-rich repeat transmembrane protein kinase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of the AtRad1p endonuclease in homologous recombination in plants. Dubest S, et al. EMBO Rep, 2002 Nov. PMID 12393748, Free PMC Article
    2. Repair of damaged DNA by Arabidopsis cell extract. Li A, et al. Plant Cell, 2002 Jan. PMID 11826311, Free PMC Article
    3. The Arabidopsis UVH1 gene is a homolog of the yeast repair endonuclease RAD1. Fidantsef AL, et al. Plant Physiol, 2000 Oct. PMID 11027708, Free PMC Article
    4. Repair of UV damage in plants by nucleotide excision repair: Arabidopsis UVH1 DNA repair gene is a homolog of Saccharomyces cerevisiae Rad1. Liu Z, et al. Plant J, 2000 Mar. PMID 10758502
    5. ERCC1/XPF protects short telomeres from homologous recombination in Arabidopsis thaliana. Vannier JB, et al. PLoS Genet, 2009 Feb. PMID 19214203, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ERCC1 and XPF protect short telomeres from homologous recombination.
      Title: ERCC1/XPF protects short telomeres from homologous recombination in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001036914.1
    NM_001344387.1
    NM_001344388.1
    NM_123480.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables single-stranded DNA endodeoxyribonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pyrimidine dimer repair by nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyrimidine dimer repair by nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to radiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Restriction endonuclease, type II-like superfamily protein
    NP_001031991.1
    • ULTRAVIOLET HYPERSENSITIVE 1 (UVH1); Has 503 Blast hits to 463 proteins in 204 species: Archae - 16; Bacteria - 0; Metazoa - 188; Fungi - 168; Plants - 53; Viruses - 0; Other Eukaryotes - 78 (source: NCBI BLink).
    NP_198931.1
    • ULTRAVIOLET HYPERSENSITIVE 1 (UVH1); CONTAINS InterPro DOMAIN/s: ERCC4 domain (InterPro:IPR006166), Restriction endonuclease, type II-like (InterPro:IPR011335), DNA repair nuclease, XPF-type/Helicase (InterPro:IPR020819); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      16472764..16477417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123480.4 → NP_198931.1  Restriction endonuclease, type II-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198931.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LKI5, Q9SE36, Q9SPL7
      UniProtKB/TrEMBL
      A0A178UNJ5, A0A5S9Y9X6, Q2F6I1
      Conserved Domains (1) summary
      TIGR00596
      Location:87 → 948
      rad1; DNA repair protein (rad1)

    2. NM_001344387.1 → NP_001330263.1  Restriction endonuclease, type II-like superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UNJ5, A0A1P8BAA2

    3. NM_001344388.1 → NP_001330264.1  Restriction endonuclease, type II-like superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JWY5

    4. NM_001036914.1 → NP_001031991.1  Restriction endonuclease, type II-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031991.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JWY5
      Conserved Domains (1) summary
      TIGR00596
      Location:87 → 689
      rad1; DNA repair protein (rad1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LKI5.2

    Gene LinkOut

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