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    THO5 THO complex, subunit 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834304, updated on 18-Sep-2024

    Summary

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    Official Symbol
    THO5
    Official Full Name
    THO complex, subunit 5
    Primary source
    TAIR:AT5G42920
    Locus tag
    AT5G42920
    See related
    Araport:AT5G42920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtTHO5; MBD2.12; MBD2_12
    Summary
    Encodes a component of the putative Arabidopsis THO/TREX complex: THO1 or HPR1 (At5g09860), THO2 (At1g24706), THO3 or TEX1 (At5g56130), THO5 (At5g42920, At1g45233), THO6 (At2g19430), and THO7 (At5g16790, At3g02950). THO/TREX complexes in animals have been implicated in the transport of mRNA precursors. Mutants of THO3/TEX1, THO1, THO6 accumulate reduced amount of small interfering (si)RNA, suggesting a role of the putative Arabidopsis THO/TREX in siRNA biosynthesis.
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    Genomic context

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    See THO5 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (17205971..17209650, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Polynucleotidyl transferase, ribonuclease H-like superfamily protein Neighboring gene Basic-leucine zipper (bZIP) transcription factor family protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene RING/U-box superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Putative Arabidopsis THO/TREX mRNA export complex is involved in transgene and endogenous siRNA biosynthesis. Yelina NE, et al. Proc Natl Acad Sci U S A, 2010 Aug 3. PMID 20634427, Free PMC Article
    2. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
    3. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_123657.3
    NM_203144.4

    Gene Ontology Provided by TAIR

    Component Evidence Code Pubs
    part_of THO complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    THO complex, subunit 5
    NP_568616.1
    • THO5; CONTAINS InterPro DOMAIN/s: THO complex, subunit 5 (InterPro:IPR019163); BEST Arabidopsis thaliana protein match is: THO complex, subunit 5 (TAIR:AT1G45233.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_974873.1
    • THO5; CONTAINS InterPro DOMAIN/s: THO complex, subunit 5 (InterPro:IPR019163); BEST Arabidopsis thaliana protein match is: THO complex, subunit 5 (TAIR:AT1G45233.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      17205971..17209650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_203144.4 → NP_974873.1  THO complex, subunit 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974873.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4K4J0, Q94BS3, Q9FMM6
      UniProtKB/TrEMBL
      A0A5S9YBJ2
      Conserved Domains (1) summary
      pfam09766
      Location:81 → 437
      FimP; Fms-interacting protein

    2. NM_123657.3 → NP_568616.1  THO complex, subunit 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568616.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9YBJ2
      Conserved Domains (1) summary
      pfam09766
      Location:1 → 320
      FimP; Fms-interacting protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4K4J0.1

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