PRMT4A protein arginine methyltransferase 4A [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: PRMT4A
Official Full Name: protein arginine methyltransferase 4A
Primary source: TAIR:AT5G49020
Locus tag: AT5G49020
See related: Araport:AT5G49020
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA PROTEIN ARGININE METHYLTRANSFERASE 4A; ATPRMT4A; K19E20.17; K19E20_17; protein arginine methyltransferase 4A
Summary: Encodes a type I protein arginine methyltransferase. PRMT4a can catalyze the asymmetric dimethylation of arginines 2,17, and 26 on histone 3 and can also methylate myelin basic protein in vitro. Double mutants lacking PRMT4a and 4b have reduced levels of histone 3 methylated at R17. These double mutants flower late due to defects in the autonomous pathway and they have elevated levels of FLC transcripts.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See PRMT4A in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 15

Sequence:: Chromosome: 5; NC_003076.8 (19871191..19874974)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

required for proper regulation of flowering time mainly through the FLOWERING LOCUS C-dependent pathway
Title: Redundant requirement for a pair of PROTEIN ARGININE METHYLTRANSFERASE4 homologs for the proper regulation of Arabidopsis flowering time.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

NM_124279.5

Supported by ESTs:

NM_203184.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables histone H3R17 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3R17 methyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables histone H3R2 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3R26 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein-arginine N-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-arginine omega-N asymmetric methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-arginine omega-N monomethyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of flower development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vegetative to reproductive phase transition of meristem	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: protein arginine methyltransferase 4A

NP_199713.2

protein arginine methyltransferase 4A (PRMT4A); CONTAINS InterPro DOMAIN/s: Skb1 methyltransferase (InterPro:IPR007857); BEST Arabidopsis thaliana protein match is: protein arginine methyltransferase 4B (TAIR:AT3G06930.1); Has 2908 Blast hits to 2887 proteins in 698 species: Archae - 60; Bacteria - 734; Metazoa - 1196; Fungi - 253; Plants - 326; Viruses - 1; Other Eukaryotes - 338 (source: NCBI BLink).

NP_974913.1

protein arginine methyltransferase 4A (PRMT4A); CONTAINS InterPro DOMAIN/s: Skb1 methyltransferase (InterPro:IPR007857); BEST Arabidopsis thaliana protein match is: protein arginine methyltransferase 4B (TAIR:AT3G06930.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

19871191..19874974

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_124279.5 → NP_199713.2 protein arginine methyltransferase 4A [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_199713.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A3KPF2, Q3E8E0, Q84WN5, Q9FI68

UniProtKB/TrEMBL

A0A178UGW2, A0A5S9YCM0

Conserved Domains (2) summary

COG0500
Location:140 → 400

SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

cl17173
Location:160 → 300

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_203184.2 → NP_974913.1 protein arginine methyltransferase 4A [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974913.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UGW2, A0A5S9YCM0

Conserved Domains (2) summary

COG0500
Location:138 → 398

SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

cl17173
Location:158 → 298

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...