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    CER3 Fatty acid hydroxylase superfamily [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835889, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CER3
    Official Full Name
    Fatty acid hydroxylase superfamily
    Primary source
    TAIR:AT5G57800
    Locus tag
    AT5G57800
    See related
    Araport:AT5G57800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ECERIFERUM 3; FACELESS POLLEN 1; FLP1; MTI20.3; MTI20_3; WAX2; YRE
    Summary
    encodes a transmembrane protein with similarity to the sterol desaturase family at the N-terminus and to the short-chain dehydrogenase/reductase family at the C-terminus. Mutant analyses indicate this protein is involved in cuticle membrane and wax biosynthesis.
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    Genomic context

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    See CER3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Sequence:
    Chromosome: 5; NC_003076.8 (23420184..23424117)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tetraspanin15 Neighboring gene Cytochrome c oxidase, subunit Vib family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel male-sterile mutant of Arabidopsis thaliana, faceless pollen-1, produces pollen with a smooth surface and an acetolysis-sensitive exine. Ariizumi T, et al. Plant Mol Biol, 2003 Sep. PMID 14756310
    2. Cloning and characterization of the WAX2 gene of Arabidopsis involved in cuticle membrane and wax production. Chen X, et al. Plant Cell, 2003 May. PMID 12724542, Free PMC Article
    3. The CER3 gene of Arabidopsis thaliana is expressed in leaves, stems, roots, flowers and apical meristems. Hannoufa A, et al. Plant J, 1996 Sep. PMID 8811860
    4. The F-Box Protein SAGL1 and ECERIFERUM3 Regulate Cuticular Wax Biosynthesis in Response to Changes in Humidity in Arabidopsis. Kim H, et al. Plant Cell, 2019 Sep. PMID 31320482, Free PMC Article
    5. The CER3 wax biosynthetic gene from Arabidopsis thaliana is allelic to WAX2/YRE/FLP1. Rowland O, et al. FEBS Lett, 2007 Jul 24. PMID 17624331

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis (Arabidopsis thaliana) Kelch repeat F-box protein SMALL AND GLOSSY LEAVES1 (SAGL1) mediates proteasome-dependent degradation of ECERIFERUM3 (CER3), a biosynthetic enzyme involved in the production of very long chain alkanes (the major components of wax), thereby negatively regulating cuticular wax biosynthesis.
      Title: The F-Box Protein SAGL1 and ECERIFERUM3 Regulate Cuticular Wax Biosynthesis in Response to Changes in Humidity in Arabidopsis.
    2. Collectively, the data demonstrate that GCN5 is involved in stem cuticular wax accumulation by modulating CER3 expression via H3K9/14 acetylation, which underlines the important role of histone acetylation in cuticular wax biosynthesis.
      Title: GCN5 contributes to stem cuticular wax biosynthesis by histone acetylation of CER3 in Arabidopsis.
    3. CER1 interacts with both CER3 and CYTB5 to catalyze the redox-dependent synthesis of very-long-chain (VLC) alkanes from VLC acyl-CoAs.
      Title: Reconstitution of plant alkane biosynthesis in yeast demonstrates that Arabidopsis ECERIFERUM1 and ECERIFERUM3 are core components of a very-long-chain alkane synthesis complex.
    4. CER3 is not At5g02310 and instead corresponds to WAX2/YRE/FLP1 (At5g57800), a gene of unknown function required for wax biosynthesis
      Title: The CER3 wax biosynthetic gene from Arabidopsis thaliana is allelic to WAX2/YRE/FLP1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_125164.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables aldehyde oxygenase (deformylating) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within alkane biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cutin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen sperm cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within wax biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    Fatty acid hydroxylase superfamily
    NP_200588.2
    • ECERIFERUM 3 (CER3); FUNCTIONS IN: oxidoreductase activity, binding, iron ion binding, catalytic activity; INVOLVED IN: cuticle hydrocarbon biosynthetic process, response to salt stress, pollen sperm cell differentiation, wax biosynthetic process, cuticle development; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NAD(P)-binding domain (InterPro:IPR016040), Fatty acid hydroxylase (InterPro:IPR006694), Uncharacterised protein, Wax2 C-terminal (InterPro:IPR021940); BEST Arabidopsis thaliana protein match is: Fatty acid hydroxylase superfamily (TAIR:AT1G02205.2); Has 879 Blast hits to 877 proteins in 232 species: Archae - 0; Bacteria - 279; Metazoa - 24; Fungi - 149; Plants - 340; Viruses - 0; Other Eukaryotes - 87 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23420184..23424117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125164.3 → NP_200588.2  Fatty acid hydroxylase superfamily [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200588.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8H1Z0, Q94B63, Q9FJN4
      UniProtKB/TrEMBL
      A0A178UEJ5, A0A5S9YFG4, A0A7G2FH26
      Conserved Domains (1) summary
      PLN02869
      Location:5 → 623
      PLN02869; fatty aldehyde decarbonylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8H1Z0.1

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