U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Klhl1 kelch-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 93688, updated on 27-Nov-2024

    Summary

    Official Symbol
    Klhl1provided by MGI
    Official Full Name
    kelch-like 1provided by MGI
    Primary source
    MGI:MGI:2136335
    See related
    Ensembl:ENSMUSG00000022076 AllianceGenome:MGI:2136335
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1490
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Acts upstream of or within adult walking behavior; cerebellar Purkinje cell layer development; and dendrite development. Located in dendrite and neuronal cell body. Is expressed in brain; extrinsic ocular muscle; and ventral grey horn. Orthologous to human KLHL1 (kelch like family member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 3.1), whole brain E14.5 (RPKM 2.5) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Klhl1 in Genome Data Viewer
    Location:
    14 E2.1; 14 46.92 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (96342695..96756525, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (96105265..96519034, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene AFG3(ATPase family gene 3)-like 1 pseudogene Neighboring gene methylmalonic aciduria cblC type, with homocystinuria pseudogene Neighboring gene predicted gene, 24043 Neighboring gene predicted gene, 25133 Neighboring gene STARR-seq mESC enhancer starr_37408 Neighboring gene STARR-seq mESC enhancer starr_37409 Neighboring gene guanine nucleotide binding protein (G protein), beta 1, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1490

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    kelch-like protein 1
    Names
    kelch-l like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053105.3NP_444335.2  kelch-like protein 1

      See identical proteins and their annotated locations for NP_444335.2

      Status: VALIDATED

      Source sequence(s)
      AC131920, AC131989, AC154580, CT025590
      Consensus CDS
      CCDS27308.1
      UniProtKB/Swiss-Prot
      Q505E9, Q9JI74
      UniProtKB/TrEMBL
      Q8CCY1
      Related
      ENSMUSP00000022666.8, ENSMUST00000022666.9
      Conserved Domains (6) summary
      smart00612
      Location:704748
      Kelch; Kelch domain
      PHA03098
      Location:209731
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:499542
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:205308
      BTB; BTB/POZ domain
      pfam01344
      Location:498543
      Kelch_1; Kelch motif
      pfam07707
      Location:317416
      BACK; BTB And C-terminal Kelch

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      96342695..96756525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)