Dock5 dedicator of cytokinesis 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dock5provided by MGI
Official Full Name: dedicator of cytokinesis 5provided by MGI
Primary source: MGI:MGI:2652871
See related: Ensembl:ENSMUSG00000044447 AllianceGenome:MGI:2652871
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: lr2; rlc; E130320D18; 1110060D06Rik
Summary: Enables guanyl-nucleotide exchange factor activity. Involved in Rac protein signal transduction. Acts upstream of or within bone remodeling and podosome assembly. Located in cytoplasm and podosome. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; liver; lung; and myotome. Orthologous to human DOCK5 (dedicator of cytokinesis 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 5.9), small intestine adult (RPKM 4.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 34.66 cM

Exon count:: 53

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (67989377..68171021, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (67751928..67933572, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism.
Title: Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism.
DOCK5 regulates energy balance and hepatic insulin sensitivity by targeting mTORC1 signaling.
Title: DOCK5 regulates energy balance and hepatic insulin sensitivity by targeting mTORC1 signaling.
The authors show that Dock5 is as a new regulator of microtubule dynamic instability in osteoclast through Rac-dependent and -independent pathways.
Title: Dock5 is a new regulator of microtubule dynamic instability in osteoclasts.
Dock5 and tensin 3 cooperate for osteoclast activity, to ensure the correct organization of podosomes.
Title: Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity.
Tensin3 is a versatile regulator of DOCK5 signaling and cell adhesion. (Review)
Title: Tensins are versatile regulators of Rho GTPase signalling and cell adhesion.
together with DOCK2 contributes to chemotaxis, reactive oxygen species production, and extracellular trap formation
Title: DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation.
Dock1 and Dock5 are not the important exchange factors regulating Rac activity during the establishment and maintenance of the glomerular barrier
Title: The Rac-specific exchange factors Dock1 and Dock5 are dispensable for the establishment of the glomerular filtration barrier in vivo.
results thus identify DOCK5 as a key signaling adaptor that orchestrates remodeling of the microtubule network essential for mast cell degranulation.
Title: DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation.
The atypical Rac1 exchange factor Dock5 is necessary for osteoclast function both in vitro and in vivo.
Title: The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclasts.
Generated an mDock5-specific antibody, which detected denatured and nascent forms of mDock5. Determined tissue-specific expression patterns and subcellular localization of mDock5 using this antibody.
Title: Characterization of an mDock5-specific antibody and tissue-specific expression and subcellular localization of mDock5.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Associated conditions

Description	Tests
rupture of lens cataract GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Gene trapped (2) 1 citation
Spontaneous (1) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D14Mit223.1 (e-PCR), detects polymorphism
- UniSTS:127338

D14Mit223.2 (e-PCR), detects polymorphism
- UniSTS:127339

AI666732 (e-PCR)
- UniSTS:164563

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Rac protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within bone remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IEA Inferred from Electronic Annotation more info
involved_in myoblast fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of vascular associated smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular associated smooth muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within podosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of vascular associated smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in podosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dedicator of cytokinesis protein 5

Names: lens rupture 2; lens rupture protein 2; rupture of lens cataract protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177780.3 → NP_808448.2 dedicator of cytokinesis protein 5

See identical proteins and their annotated locations for NP_808448.2

Status: VALIDATED

Source sequence(s)

AC090431, AC093020, AK004325, AK147975, BC050992, CF746784

Consensus CDS

CCDS36963.1

UniProtKB/Swiss-Prot

B2RY04, E9QLI4

Related

ENSMUSP00000036674.5, ENSMUST00000039135.6

Conserved Domains (4) summary

cd11708
Location:1238 → 1637

DHR2_DOCK5; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 5

cd12051
Location:12 → 67

SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5

pfam16172
Location:75 → 434

DOCK_N; DOCK N-terminus

cl14603
Location:442 → 637

C2; C2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

67989377..68171021 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245170.3 → XP_011243472.1 dedicator of cytokinesis protein 5 isoform X1

Conserved Domains (4) summary

cd11708
Location:1229 → 1628

DHR2_DOCK5; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 5

pfam16172
Location:66 → 425

DOCK_N; DOCK N-terminus

cl14603
Location:433 → 628

C2; C2 domain

cl17036
Location:6 → 58

SH3; Src Homology 3 domain superfamily