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    LACS6 long-chain acyl-CoA synthetase 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819767, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LACS6
    Official Full Name
    long-chain acyl-CoA synthetase 6
    Primary source
    TAIR:AT3G05970
    Locus tag
    AT3G05970
    See related
    Araport:AT3G05970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATLACS6; F2O10.7; F2O10_7; long-chain acyl-CoA synthetase 6
    Summary
    encode peroxisomal long-chain acyl-CoA synthetase (LACS) isozymes
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    Genomic context

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    See LACS6 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    23
    Sequence:
    Chromosome: 3; NC_003074.8 (1786279..1791887, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RmlC-like cupins superfamily protein Neighboring gene sugar transporter 6 Neighboring gene Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two long-chain acyl-CoA synthetases from Arabidopsis thaliana involved in peroxisomal fatty acid beta-oxidation. Fulda M, et al. Plant J, 2002 Oct. PMID 12366803
    2. Intrinsic acyl-CoA thioesterase activity of a peroxisomal ATP binding cassette transporter is required for transport and metabolism of fatty acids. De Marcos Lousa C, et al. Proc Natl Acad Sci U S A, 2013 Jan 22. PMID 23288899, Free PMC Article
    3. AtLACS7 interacts with the TPR domains of the PTS1 receptor PEX5. Bonsegna S, et al. Arch Biochem Biophys, 2005 Nov 15. PMID 16256065
    4. Arabidopsis contains nine long-chain acyl-coenzyme a synthetase genes that participate in fatty acid and glycerolipid metabolism. Shockey JM, et al. Plant Physiol, 2002 Aug. PMID 12177484, Free PMC Article
    5. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_111471.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables long-chain fatty acid-CoA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within long-chain fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in response to ozone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    long-chain acyl-CoA synthetase 6
    NP_566265.1
    • long-chain acyl-CoA synthetase 6 (LACS6); FUNCTIONS IN: long-chain fatty acid-CoA ligase activity; INVOLVED IN: long-chain fatty acid metabolic process; LOCATED IN: membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: long-chain acyl-CoA synthetase 7 (TAIR:AT5G27600.1); Has 54528 Blast hits to 52136 proteins in 3333 species: Archae - 925; Bacteria - 35165; Metazoa - 2570; Fungi - 2253; Plants - 2087; Viruses - 1; Other Eukaryotes - 11527 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1786279..1791887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111471.3 → NP_566265.1  long-chain acyl-CoA synthetase 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566265.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LKS6, Q8LPS1, Q9C5U7, Q9SFG1
      UniProtKB/TrEMBL
      A0A178VG06, A0A5S9X9I0
      Conserved Domains (1) summary
      PLN02736
      Location:41 → 691
      PLN02736; long-chain acyl-CoA synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LPS1.1

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