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    GLY3 glyoxalase II 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841793, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GLY3
    Official Full Name
    glyoxalase II 3
    Primary source
    TAIR:AT1G53580
    Locus tag
    AT1G53580
    See related
    Araport:AT1G53580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ETHE1; ETHE1-LIKE; ETHYLMALONIC ENCEPHALOPATHY PROTEIN1; F22G10.9; GLX2-3; GLYOXALASE 2-3; glyoxalase II 3; glyoxalase II 3; T3F20.11; T3F20_11
    Summary
    Mononuclear Fe(II)-containing member of the b-lactamase fold superfamily. ETHE1 is homodimeric in solution, exhibits low-level esterase activity, and specifically binds a single Fe(II) atom in the active site.
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    Genomic context

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    See GLY3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (19991271..19993458, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box family protein Neighboring gene Ribosomal protein L18ae family Neighboring gene mitogen-activated protein kinase kinase kinase 3 Neighboring gene Calcium-dependent lipid-binding (CaLB domain) family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mitochondrial sulfur dioxygenase ETHYLMALONIC ENCEPHALOPATHY PROTEIN1 is required for amino acid catabolism during carbohydrate starvation and embryo development in Arabidopsis. Krüßel L, et al. Plant Physiol, 2014 May. PMID 24692429, Free PMC Article
    2. Arabidopsis ETHE1 encodes a sulfur dioxygenase that is essential for embryo and endosperm development. Holdorf MM, et al. Plant Physiol, 2012 Sep. PMID 22786886, Free PMC Article
    3. Spectroscopic studies on Arabidopsis ETHE1, a glyoxalase II-like protein. Holdorf MM, et al. J Inorg Biochem, 2008 Sep. PMID 18656261, Free PMC Article
    4. Structure of an ETHE1-like protein from Arabidopsis thaliana. McCoy JG, et al. Acta Crystallogr D Biol Crystallogr, 2006 Sep. PMID 16929096
    5. Proteome analysis of peroxisomes from dark-treated senescent Arabidopsis leaves. Pan R, et al. J Integr Plant Biol, 2018 Nov. PMID 29877633

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ETHE1 also affects the oxidation of branched-chain amino acids and lysine.
      Title: The mitochondrial sulfur dioxygenase ETHYLMALONIC ENCEPHALOPATHY PROTEIN1 is required for amino acid catabolism during carbohydrate starvation and embryo development in Arabidopsis.
    2. ETHE1 is esential for early seed development.
      Title: Arabidopsis ETHE1 encodes a sulfur dioxygenase that is essential for embryo and endosperm development.
    3. structural comparison of human ETHE1 and At1g53580 from Arabidopsis thaliana
      Title: Structure of an ETHE1-like protein from Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_104236.5
    NM_202289.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables glutathione thiolesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, acting on ester bonds IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfur dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfur dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endosperm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glutathione metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within seed development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    glyoxalase II 3
    NP_564636.2
    • glyoxalase II 3 (GLY3); FUNCTIONS IN: hydrolase activity, acting on ester bonds, hydroxyacylglutathione hydrolase activity; INVOLVED IN: response to salt stress, methylglyoxal catabolic process to D-lactate; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Beta-lactamase-like (InterPro:IPR001279); BEST Arabidopsis thaliana protein match is: Metallo-hydrolase/oxidoreductase superfamily protein (TAIR:AT3G10850.1); Has 13610 Blast hits to 13607 proteins in 2472 species: Archae - 279; Bacteria - 8978; Metazoa - 399; Fungi - 229; Plants - 189; Viruses - 0; Other Eukaryotes - 3536 (source: NCBI BLink).
    NP_974018.3
    • glyoxalase II 3 (GLY3); FUNCTIONS IN: hydrolase activity, acting on ester bonds, hydroxyacylglutathione hydrolase activity; INVOLVED IN: response to salt stress, methylglyoxal catabolic process to D-lactate; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Beta-lactamase-like (InterPro:IPR001279); BEST Arabidopsis thaliana protein match is: Metallo-hydrolase/oxidoreductase superfamily protein (TAIR:AT3G10850.1); Has 13580 Blast hits to 13577 proteins in 2470 species: Archae - 281; Bacteria - 8959; Metazoa - 398; Fungi - 229; Plants - 189; Viruses - 0; Other Eukaryotes - 3524 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      19991271..19993458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104236.5 → NP_564636.2  glyoxalase II 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564636.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93VR2, Q96332, Q9C8L4, Q9LPH3
      UniProtKB/TrEMBL
      A0A5S9WPC7
      Conserved Domains (2) summary
      PLN02962
      Location:51 → 292
      PLN02962; hydroxyacylglutathione hydrolase
      cd07724
      Location:53 → 234
      POD-like_MBL-fold; ETHE1 (PDO type I), persulfide dioxygenase A (PDOA, PDO type II) and related proteins; MBL-fold metallo-hydrolase domain

    2. NM_202289.3 → NP_974018.3  glyoxalase II 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974018.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WPC7, F4HRK0
      Conserved Domains (2) summary
      PLN02962
      Location:51 → 292
      PLN02962; hydroxyacylglutathione hydrolase
      cd07724
      Location:53 → 234
      POD-like_MBL-fold; ETHE1 (PDO type I), persulfide dioxygenase A (PDOA, PDO type II) and related proteins; MBL-fold metallo-hydrolase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C8L4.3

    Gene LinkOut

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