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    MIRO1 MIRO-related GTP-ase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832814, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MIRO1
    Official Full Name
    MIRO-related GTP-ase 1
    Primary source
    TAIR:AT5G27540
    Locus tag
    AT5G27540
    See related
    Araport:AT5G27540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    emb2473; embryo defective 2473; F21A20.250; F21A20_250; MIRO-related GTP-ase 1
    Summary
    Encodes a protein with similarity to GTPases that is localized to the mitochondrion. Involved in embryogenesis, pollen tube growth and required for mitochondrial development.
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    Genomic context

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    See MIRO1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    15
    Sequence:
    Chromosome: 5; NC_003076.8 (9722416..9727454)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene peroxisomal adenine nucleotide carrier 2 Neighboring gene Pectin lyase-like superfamily protein Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene DUF1995 domain protein, putative (DUF1995) Neighboring gene cell division cycle 20.2, cofactor of APC complex-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MIRO1 influences the morphology and intracellular distribution of mitochondria during embryonic cell division in Arabidopsis. Yamaoka S, et al. Plant Cell Rep, 2011 Feb. PMID 20931334
    2. Arabidopsis thaliana MIRO1 and MIRO2 GTPases are unequally redundant in pollen tube growth and fusion of polar nuclei during female gametogenesis. Sørmo CG, et al. PLoS One, 2011 Apr 11. PMID 21494602, Free PMC Article
    3. EMB2473/MIRO1, an Arabidopsis Miro GTPase, is required for embryogenesis and influences mitochondrial morphology in pollen. Yamaoka S, et al. Plant Cell, 2008 Mar. PMID 18344283, Free PMC Article
    4. The hydrophobic proteome of mitochondrial membranes from Arabidopsis cell suspensions. Brugière S, et al. Phytochemistry, 2004 Jun. PMID 15276431
    5. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MIRO1 and MIRO2 are unequally redundant and that a proportion of the miro1(+/-)/miro2(-/-) plants haploid gametes displays the complete null phenotype of MIRO GTPase function at key developmental stages.
      Title: Arabidopsis thaliana MIRO1 and MIRO2 GTPases are unequally redundant in pollen tube growth and fusion of polar nuclei during female gametogenesis.
    2. proper mitochondrial morphology and intracellular distribution are maintained by MIRO1 and are vital for embryonic cell division
      Title: MIRO1 influences the morphology and intracellular distribution of mitochondria during embryonic cell division in Arabidopsis.
    3. Findings suggest that mitochondrial morphology is influenced by MIRO1 and plays a vital role during embryogenesis and pollen tube growth.
      Title: EMB2473/MIRO1, an Arabidopsis Miro GTPase, is required for embryogenesis and influences mitochondrial morphology in pollen.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001036876.2
    NM_122636.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    MIRO-related GTP-ase 1
    NP_001031953.1
    • MIRO-related GTP-ase 1 (MIRO1); FUNCTIONS IN: GTP binding; INVOLVED IN: pollen tube growth, mitochondrion organization, embryo development, embryo development ending in seed dormancy; LOCATED IN: mitochondrion; EXPRESSED IN: 31 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF hand associated, type-1 (InterPro:IPR013566), Mitochondrial Rho-like (InterPro:IPR013684), EF hand associated, type-2 (InterPro:IPR013567), Ras GTPase (InterPro:IPR001806), Small GTP-binding protein (InterPro:IPR005225), Small GTPase (InterPro:IPR020851), Mitochondrial Rho GTPase (InterPro:IPR021181), MIRO (InterPro:IPR020860); BEST Arabidopsis thaliana protein match is: MIRO-related GTP-ase 2 (TAIR:AT3G63150.1); Has 8016 Blast hits to 7980 proteins in 467 species: Archae - 6; Bacteria - 176; Metazoa - 4167; Fungi - 1485; Plants - 887; Viruses - 0; Other Eukaryotes - 1295 (source: NCBI BLink).
    NP_198106.1
    • MIRO-related GTP-ase 1 (MIRO1); FUNCTIONS IN: GTP binding; INVOLVED IN: pollen tube growth, mitochondrion organization, embryo development, embryo development ending in seed dormancy; LOCATED IN: mitochondrion; EXPRESSED IN: 31 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF hand associated, type-1 (InterPro:IPR013566), Mitochondrial Rho-like (InterPro:IPR013684), EF hand associated, type-2 (InterPro:IPR013567), Ras GTPase (InterPro:IPR001806), Small GTP-binding protein (InterPro:IPR005225), Small GTPase (InterPro:IPR020851), Mitochondrial Rho GTPase (InterPro:IPR021181), MIRO (InterPro:IPR020860); BEST Arabidopsis thaliana protein match is: MIRO-related GTP-ase 2 (TAIR:AT3G63150.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      9722416..9727454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001036876.2 → NP_001031953.1  MIRO-related GTP-ase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031953.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RXF8
      UniProtKB/TrEMBL
      A0A178UBE1, A0A5S9Y8T3
      Conserved Domains (4) summary
      cd01892
      Location:426 → 608
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:16 → 183
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:356 → 410
      EF_assoc_1; EF hand associated
      pfam08356
      Location:233 → 317
      EF_assoc_2; EF hand associated

    2. NM_122636.4 → NP_198106.1  MIRO-related GTP-ase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198106.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RXF8
      UniProtKB/TrEMBL
      A0A178UBE1, A0A5S9Y8T3
      Conserved Domains (4) summary
      cd01892
      Location:426 → 608
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:16 → 183
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:356 → 410
      EF_assoc_1; EF hand associated
      pfam08356
      Location:233 → 317
      EF_assoc_2; EF hand associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8RXF8.1

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