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    SAPX stromal ascorbate peroxidase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826396, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SAPX
    Official Full Name
    stromal ascorbate peroxidase
    Primary source
    TAIR:AT4G08390
    Locus tag
    AT4G08390
    See related
    Araport:AT4G08390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    stromal ascorbate peroxidase; STROMAL ASCORBATE PEROXIDASE; T28D5.80; T28D5_80
    Summary
    Encodes a chloroplastic stromal ascorbate peroxidase sAPX. Ascorbate peroxidases are enzymes that scavenge hydrogen peroxide in plant cells. Eight types of APX have been described for Arabidopsis: three cytosolic (APX1, APX2, APX6), two chloroplastic types (stromal sAPX, thylakoid tAPX), and three microsomal (APX3, APX4, APX5) isoforms.
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    Genomic context

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    See SAPX in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    12
    Sequence:
    Chromosome: 4; NC_003075.7 (5314871..5317963)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Proline-rich extensin-like family protein Neighboring gene ncRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cold priming on pathogen susceptibility in the Arabidopsis eds1 mutant background requires a functional stromal Ascorbate Peroxidase. Schütte D, et al. Plant Signal Behav, 2024 Dec 31. PMID 38170666, Free PMC Article
    2. Molecular definition of the ascorbate-glutathione cycle in Arabidopsis mitochondria reveals dual targeting of antioxidant defenses in plants. Chew O, et al. J Biol Chem, 2003 Nov 21. PMID 12954611
    3. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article
    4. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article
    5. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cold priming on pathogen susceptibility in the Arabidopsis eds1 mutant background requires a functional stromal Ascorbate Peroxidase.
      Title: Cold priming on pathogen susceptibility in the Arabidopsis eds1 mutant background requires a functional stromal Ascorbate Peroxidase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001084887.2
    NM_001203761.1
    NM_001340582.1
    NM_116908.3
    NM_202791.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-ascorbate peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    stromal ascorbate peroxidase
    NP_001078356.2
    • stromal ascorbate peroxidase (SAPX); FUNCTIONS IN: L-ascorbate peroxidase activity; INVOLVED IN: oxidation reduction, response to oxidative stress; LOCATED IN: mitochondrion, chloroplast stroma, chloroplast, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Haem peroxidase (InterPro:IPR010255), Plant ascorbate peroxidase (InterPro:IPR002207), Peroxidases heam-ligand binding site (InterPro:IPR019793), Haem peroxidase, plant/fungal/bacterial (InterPro:IPR002016); BEST Arabidopsis thaliana protein match is: thylakoidal ascorbate peroxidase (TAIR:AT1G77490.1); Has 9797 Blast hits to 7922 proteins in 1252 species: Archae - 60; Bacteria - 2389; Metazoa - 388; Fungi - 725; Plants - 3386; Viruses - 0; Other Eukaryotes - 2849 (source: NCBI BLink).
    NP_001190690.1
    • stromal ascorbate peroxidase (SAPX); FUNCTIONS IN: L-ascorbate peroxidase activity; INVOLVED IN: oxidation reduction, response to oxidative stress; LOCATED IN: mitochondrion, chloroplast stroma; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Haem peroxidase (InterPro:IPR010255), Plant ascorbate peroxidase (InterPro:IPR002207), Peroxidases heam-ligand binding site (InterPro:IPR019793), Haem peroxidase, plant/fungal/bacterial (InterPro:IPR002016); BEST Arabidopsis thaliana protein match is: thylakoidal ascorbate peroxidase (TAIR:AT1G77490.1).
    NP_001319883.1
    • stromal ascorbate peroxidase (SAPX); FUNCTIONS IN: L-ascorbate peroxidase activity; INVOLVED IN: response to oxidative stress, oxidation reduction; LOCATED IN: mitochondrion, chloroplast stroma, chloroplast, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Haem peroxidase (InterPro:IPR010255), Plant ascorbate peroxidase (InterPro:IPR002207), Peroxidases heam-ligand binding site (InterPro:IPR019793), Haem peroxidase, plant/fungal/bacterial (InterPro:IPR002016); BEST Arabidopsis thaliana protein match is: thylakoidal ascorbate peroxidase (TAIR:AT1G77490.1); Has 10581 Blast hits to 8285 proteins in 1297 species: Archae - 72; Bacteria - 2483; Metazoa - 532; Fungi - 1068; Plants - 3384; Viruses - 0; Other Eukaryotes - 3042 (source: NCBI BLink).
    NP_974520.1
    • stromal ascorbate peroxidase (SAPX); FUNCTIONS IN: L-ascorbate peroxidase activity; INVOLVED IN: response to oxidative stress, oxidation reduction; LOCATED IN: mitochondrion, chloroplast stroma, chloroplast, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Haem peroxidase (InterPro:IPR010255), Plant ascorbate peroxidase (InterPro:IPR002207), Peroxidases heam-ligand binding site (InterPro:IPR019793), Haem peroxidase, plant/fungal/bacterial (InterPro:IPR002016); BEST Arabidopsis thaliana protein match is: thylakoidal ascorbate peroxidase (TAIR:AT1G77490.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      5314871..5317963
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001340582.1 → NP_001319883.1  stromal ascorbate peroxidase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q42592, Q9STM9
      UniProtKB/TrEMBL
      A0A178V0Q5

    2. NM_116908.3 → NP_192579.1  stromal ascorbate peroxidase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192579.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q42592, Q9STM9
      UniProtKB/TrEMBL
      A0A178V0Q5
      Conserved Domains (1) summary
      cd00691
      Location:95 → 365
      ascorbate_peroxidase; Ascorbate peroxidases and cytochrome C peroxidases

    3. NM_001203761.1 → NP_001190690.1  stromal ascorbate peroxidase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190690.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V0Q5, F4JFY4
      Conserved Domains (1) summary
      cd00691
      Location:95 → 339
      ascorbate_peroxidase; Ascorbate peroxidases and cytochrome C peroxidases

    4. NM_001084887.2 → NP_001078356.2  stromal ascorbate peroxidase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078356.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V0Q5, F4JFY5
      Conserved Domains (1) summary
      cd00691
      Location:94 → 364
      ascorbate_peroxidase; Ascorbate peroxidases and cytochrome C peroxidases

    5. NM_202791.3 → NP_974520.1  stromal ascorbate peroxidase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974520.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q42592, Q9STM9
      UniProtKB/TrEMBL
      A0A178V0Q5
      Conserved Domains (1) summary
      cd00691
      Location:95 → 365
      ascorbate_peroxidase; Ascorbate peroxidases and cytochrome C peroxidases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q42592.2

    Gene LinkOut

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