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    KASI 3-ketoacyl-acyl carrier protein synthase I [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834671, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KASI
    Official Full Name
    3-ketoacyl-acyl carrier protein synthase I
    Primary source
    TAIR:AT5G46290
    Locus tag
    AT5G46290
    See related
    Araport:AT5G46290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    3-ketoacyl-acyl carrier protein synthase I; 3-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE I; KAS1; KETOACYL-ACP SYNTHASE 1; MPL12.7; MPL12_7
    Summary
    Encodes beta-ketoacyl-[acyl carrier protein] synthase I (KASI). Crucial for fatty acid synthesis. Plays a role in chloroplast division and embryo development.
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    Genomic context

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    See KASI in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (18774056..18776839, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Minichromosome maintenance (MCM2/3/5) family protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis β-ketoacyl-[acyl carrier protein] synthase i is crucial for fatty acid synthesis and plays a role in chloroplast division and embryo development. Wu GZ, et al. Plant Cell, 2010 Nov. PMID 21081696, Free PMC Article
    2. Redox Conformation-Specific Protein-Protein Interactions of the 2-Cysteine Peroxiredoxin in Arabidopsis. Liebthal M, et al. Antioxidants (Basel), 2020 Jun 11. PMID 32545358, Free PMC Article
    3. The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Peltier JB, et al. Mol Cell Proteomics, 2006 Jan. PMID 16207701
    4. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article
    5. Proteomic study of the Arabidopsis thaliana chloroplastic envelope membrane utilizing alternatives to traditional two-dimensional electrophoresis. Froehlich JE, et al. J Proteome Res, 2003 Jul-Aug. PMID 12938931

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data report the functional characterization of KASI in the regulation of chloroplast division and embryo development, and show that the polar lipid supply is important for chloroplast division and development.
      Title: Arabidopsis β-ketoacyl-[acyl carrier protein] synthase i is crucial for fatty acid synthesis and plays a role in chloroplast division and embryo development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036941.1
    NM_001203550.1
    NM_123998.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    3-ketoacyl-acyl carrier protein synthase I
    NP_001032018.1
    • 3-ketoacyl-acyl carrier protein synthase I (KAS I); FUNCTIONS IN: fatty acid synthase activity, catalytic activity; INVOLVED IN: biosynthetic process, metabolic process; LOCATED IN: chloroplast, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Beta-ketoacyl synthase (InterPro:IPR000794), Thiolase-like (InterPro:IPR016039), Beta-ketoacyl synthase, C-terminal (InterPro:IPR014031), Beta-ketoacyl synthase, N-terminal (InterPro:IPR014030), Thiolase-like, subgroup (InterPro:IPR016038); BEST Arabidopsis thaliana protein match is: fatty acid biosynthesis 1 (TAIR:AT1G74960.3); Has 30963 Blast hits to 27081 proteins in 3527 species: Archae - 8; Bacteria - 22396; Metazoa - 501; Fungi - 1760; Plants - 376; Viruses - 0; Other Eukaryotes - 5922 (source: NCBI BLink).
    NP_001190479.1
    • 3-ketoacyl-acyl carrier protein synthase I (KAS I); FUNCTIONS IN: transferase activity, transferring acyl groups other than amino-acyl groups, fatty acid synthase activity, catalytic activity; INVOLVED IN: biosynthetic process, metabolic process, fatty acid biosynthetic process; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Beta-ketoacyl synthase (InterPro:IPR000794), Beta-ketoacyl synthase, C-terminal (InterPro:IPR014031), 3-oxoacyl-[acyl-carrier-protein] synthase 2 (InterPro:IPR017568), Beta-ketoacyl synthase, N-terminal (InterPro:IPR014030), Beta-ketoacyl synthase, active site (InterPro:IPR018201), Thiolase-like, subgroup (InterPro:IPR016038), Thiolase-like (InterPro:IPR016039), Polyketide synthase, beta-ketoacyl synthase region (InterPro:IPR020841); BEST Arabidopsis thaliana protein match is: fatty acid biosynthesis 1 (TAIR:AT1G74960.3).
    NP_199441.1
    • 3-ketoacyl-acyl carrier protein synthase I (KAS I); FUNCTIONS IN: transferase activity, transferring acyl groups other than amino-acyl groups, fatty acid synthase activity, catalytic activity; INVOLVED IN: biosynthetic process, metabolic process, fatty acid biosynthetic process; LOCATED IN: chloroplast, chloroplast stroma, membrane, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Beta-ketoacyl synthase (InterPro:IPR000794), Polyketide synthase, beta-ketoacyl synthase region (InterPro:IPR020841), Thiolase-like (InterPro:IPR016039), Beta-ketoacyl synthase, C-terminal (InterPro:IPR014031), 3-oxoacyl-[acyl-carrier-protein] synthase 2 (InterPro:IPR017568), Beta-ketoacyl synthase, N-terminal (InterPro:IPR014030), Thiolase-like, subgroup (InterPro:IPR016038), Beta-ketoacyl synthase, active site (InterPro:IPR018201); BEST Arabidopsis thaliana protein match is: fatty acid biosynthesis 1 (TAIR:AT1G74960.3); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      18774056..18776839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123998.3 → NP_199441.1  3-ketoacyl-acyl carrier protein synthase I [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199441.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P52410, Q2V312, Q9FL32
      UniProtKB/TrEMBL
      A0A178UMH0, A0A5S9YBT2
      Conserved Domains (1) summary
      cd00834
      Location:61 → 468
      KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...

    2. NM_001203550.1 → NP_001190479.1  3-ketoacyl-acyl carrier protein synthase I [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190479.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4KHF4
      Conserved Domains (2) summary
      PRK06333
      Location:59 → 489
      PRK06333; 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed
      cd00834
      Location:61 → 484
      KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...

    3. NM_001036941.1 → NP_001032018.1  3-ketoacyl-acyl carrier protein synthase I [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001032018.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P52410
      Conserved Domains (2) summary
      cd00834
      Location:61 → 413
      KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...
      TIGR03150
      Location:61 → 413
      fabF; beta-ketoacyl-acyl-carrier-protein synthase II
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52410.2

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