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    TRP1 tryptophan biosynthesis 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831666, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TRP1
    Official Full Name
    tryptophan biosynthesis 1
    Primary source
    TAIR:AT5G17990
    Locus tag
    AT5G17990
    See related
    Araport:AT5G17990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MCM23.6; MCM23_6; pat1; PHOSPHORIBOSYLANTHRANILATE TRANSFERASE; PHOSPHORIBOSYLANTHRANILATE TRANSFERASE 1; tryptophan biosynthesis 1
    Summary
    Encodes the tryptophan biosynthetic enzyme phosphoribosylanthranilate transferase (PAT1, called trpD in bacteria). Converts anthranilate and phosphoribosylpyrophosphate into phosphoribosylanthranilate and inorganic pyrophosphate.
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    Genomic context

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    See TRP1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (5957080..5960201)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene C2 calcium/lipid-binding plant phosphoribosyltransferase family protein Neighboring gene VERDANDI Neighboring gene tRNA-Trp Neighboring gene SAUR-like auxin-responsive protein family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Introns act post-transcriptionally to increase expression of the Arabidopsis thaliana tryptophan pathway gene PAT1. Rose AB, et al. Plant J, 1997 Mar. PMID 9107035
    2. An allelic series of blue fluorescent trp1 mutants of Arabidopsis thaliana. Rose AB, et al. Genetics, 1997 Jan. PMID 9017401, Free PMC Article
    3. AtTRP1 encodes a novel TPR protein that interacts with the ethylene receptor ERS1 and modulates development in Arabidopsis. Lin Z, et al. J Exp Bot, 2009. PMID 19567478, Free PMC Article
    4. A C-terminal Myb extension domain defines a novel family of double-strand telomeric DNA-binding proteins in Arabidopsis. Karamysheva ZN, et al. J Biol Chem, 2004 Nov 12. PMID 15364931
    5. Proximity labeling of protein complexes and cell-type-specific organellar proteomes in Arabidopsis enabled by TurboID. Mair A, et al. Elife, 2019 Sep 19. PMID 31535972, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NM_121804.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables anthranilate phosphoribosyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tryptophan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tryptophan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    tryptophan biosynthesis 1
    NP_197300.1
    • tryptophan biosynthesis 1 (TRP1); FUNCTIONS IN: anthranilate phosphoribosyltransferase activity; INVOLVED IN: tryptophan biosynthetic process; LOCATED IN: chloroplast stroma, chloroplast, chloroplast envelope; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Glycosyl transferase, family 3, N-terminal (InterPro:IPR017459), Anthranilate phosphoribosyl transferase (InterPro:IPR005940), Glycosyl transferase, family 3 (InterPro:IPR000312); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5957080..5960201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121804.5 → NP_197300.1  tryptophan biosynthesis 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197300.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q02166, Q42557
      UniProtKB/TrEMBL
      A0A178U8D1, Q547D7
      Conserved Domains (1) summary
      PLN02641
      Location:105 → 444
      PLN02641; anthranilate phosphoribosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02166.1

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