U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ATR2 P450 reductase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829144, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ATR2
    Official Full Name
    P450 reductase 2
    Primary source
    TAIR:AT4G30210
    Locus tag
    AT4G30210
    See related
    Araport:AT4G30210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AR2; F9N11.60; F9N11_60; P450 reductase 2
    Summary
    Encodes NADPH-cytochrome P450 reductase that catalyzes the first oxidative step of the phenylpropanoid general pathway.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ATR2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    17
    Sequence:
    Chromosome: 4; NC_003075.7 (14796695..14800961)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene H[+]-ATPase 2 Neighboring gene vernalization5/VIN3-like protein Neighboring gene small nuclear ribonucleoprotein F Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Structure of the Arabidopsis thaliana NADPH-cytochrome P450 reductase 2 (ATR2) provides insight into its function. Niu G, et al. FEBS J, 2017 Mar. PMID 28103421
    2. Mutation of the inducible ARABIDOPSIS THALIANA CYTOCHROME P450 REDUCTASE2 alters lignin composition and improves saccharification. Sundin L, et al. Plant Physiol, 2014 Dec. PMID 25315601, Free PMC Article
    3. Bacterial expression and purification of the Arabidopsis NADPH-cytochrome P450 reductase ATR2. Hull AK, et al. Protein Expr Purif, 2000 Apr. PMID 10733884
    4. Two isoforms of NADPH:cytochrome P450 reductase in Arabidopsis thaliana. Gene structure, heterologous expression in insect cells, and differential regulation. Mizutani M, et al. Plant Physiol, 1998 Jan. PMID 9449848, Free PMC Article
    5. Cloning, yeast expression, and characterization of the coupling of two distantly related Arabidopsis thaliana NADPH-cytochrome P450 reductases with P450 CYP73A5. Urban P, et al. J Biol Chem, 1997 Aug 1. PMID 9235908

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    NM_119167.4
    NM_179141.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NADPH-hemoprotein reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADPH-hemoprotein reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phenylpropanoid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phenylpropanoid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    P450 reductase 2
    NP_194750.1
    • P450 reductase 2 (ATR2); FUNCTIONS IN: NADPH-hemoprotein reductase activity; INVOLVED IN: phenylpropanoid metabolic process; LOCATED IN: endoplasmic reticulum, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ferredoxin reductase-type FAD-binding domain (InterPro:IPR017927), Flavodoxin/nitric oxide synthase (InterPro:IPR008254), Oxidoreductase FAD/NAD(P)-binding (InterPro:IPR001433), Riboflavin synthase-like beta-barrel (InterPro:IPR017938), FAD-binding, type 1 (InterPro:IPR003097), Flavoprotein pyridine nucleotide cytochrome reductase (InterPro:IPR001709), NADPH Cytochrome P450 Reductase (InterPro:IPR015702); BEST Arabidopsis thaliana protein match is: P450 reductase 1 (TAIR:AT4G24520.1); Has 6728 Blast hits to 6356 proteins in 1574 species: Archae - 5; Bacteria - 3354; Metazoa - 1038; Fungi - 894; Plants - 570; Viruses - 0; Other Eukaryotes - 867 (source: NCBI BLink).
    NP_849472.2
    • P450 reductase 2 (ATR2); FUNCTIONS IN: NADPH-hemoprotein reductase activity; INVOLVED IN: phenylpropanoid metabolic process; LOCATED IN: endoplasmic reticulum, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Oxidoreductase FAD/NAD(P)-binding (InterPro:IPR001433), Ferredoxin reductase-type FAD-binding domain (InterPro:IPR017927), Riboflavin synthase-like beta-barrel (InterPro:IPR017938), FAD-binding, type 1 (InterPro:IPR003097), Flavodoxin/nitric oxide synthase (InterPro:IPR008254), Flavoprotein pyridine nucleotide cytochrome reductase (InterPro:IPR001709); BEST Arabidopsis thaliana protein match is: P450 reductase 1 (TAIR:AT4G24520.1); Has 6811 Blast hits to 6438 proteins in 1585 species: Archae - 5; Bacteria - 3394; Metazoa - 1038; Fungi - 872; Plants - 570; Viruses - 0; Other Eukaryotes - 932 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      14796695..14800961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001342001.1 → NP_001328167.1  P450 reductase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B3S1, A0A654FU66

    2. NM_119167.4 → NP_194750.1  P450 reductase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194750.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JPK2, Q39036, Q9SUM3
      UniProtKB/TrEMBL
      A0A178USJ1, A0A5S9XZE6, A0A654FU66
      Conserved Domains (2) summary
      cd06204
      Location:308 → 711
      CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
      pfam00258
      Location:107 → 250
      Flavodoxin_1

    3. NM_179141.2 → NP_849472.2  P450 reductase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849472.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FU66
      Conserved Domains (3) summary
      cd06204
      Location:308 → 712
      CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
      COG0369
      Location:103 → 712
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:107 → 250
      Flavodoxin_1; Flavodoxin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SUM3.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.