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    HIT3 HIS triad family protein 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824816, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HIT3
    Official Full Name
    HIS triad family protein 3
    Primary source
    TAIR:AT3G56490
    Locus tag
    AT3G56490
    See related
    Araport:AT3G56490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    HINT1; HIS triad family protein 3; HISTIDINE TRIAD NUCLEOTIDE-BINDING 1
    Summary
    Encodes a protein that has adenylylsulfate sulfohydrolase activity (E.C. 3.6.2.1) in vitro.
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    Genomic context

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    See HIT3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (20941285..20943469)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene F-box family protein Neighboring gene ncRNA Neighboring gene myosin heavy chain-like protein Neighboring gene ncRNA Neighboring gene serine-rich protein-like protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene NAC (No Apical Meristem) domain transcriptional regulator superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo subcellular targeting analysis validates a novel peroxisome targeting signal type 2 and the peroxisomal localization of two proteins with putative functions in defense in Arabidopsis. Quan S, et al. Plant Signal Behav, 2010 Feb. PMID 20009535, Free PMC Article
    2. Dual activity of certain HIT-proteins: A. thaliana Hint4 and C. elegans DcpS act on adenosine 5'-phosphosulfate as hydrolases (forming AMP) and as phosphorylases (forming ADP). Guranowski A, et al. FEBS Lett, 2010 Jan 4. PMID 19896942
    3. In-depth proteome analysis of Arabidopsis leaf peroxisomes combined with in vivo subcellular targeting verification indicates novel metabolic and regulatory functions of peroxisomes. Reumann S, et al. Plant Physiol, 2009 May. PMID 19329564, Free PMC Article
    4. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475
    5. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_115507.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables adenylylsulfatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within purine ribonucleotide metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within sulfur compound metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in secretory vesicle HDA PubMed 

    General protein information

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    Preferred Names
    HIS triad family protein 3
    NP_567038.1
    • HIS triad family protein 3 (HIT3); FUNCTIONS IN: protein kinase C binding, adenylylsulfatase activity, zinc ion binding; INVOLVED IN: sulfur metabolic process, purine ribonucleotide metabolic process; LOCATED IN: peroxisome, plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Histidine triad-like motif (InterPro:IPR011146), Histidine triad, conserved site (InterPro:IPR019808), Histidine triad (HIT) protein (InterPro:IPR001310), Histidine triad motif (InterPro:IPR011151); BEST Arabidopsis thaliana protein match is: HISTIDINE TRIAD NUCLEOTIDE-BINDING 2 (TAIR:AT1G31160.1); Has 7957 Blast hits to 7956 proteins in 2592 species: Archae - 148; Bacteria - 4849; Metazoa - 343; Fungi - 139; Plants - 127; Viruses - 0; Other Eukaryotes - 2351 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20941285..20943469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115507.4 → NP_567038.1  HIS triad family protein 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567038.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GUN2, Q9LXZ1
      UniProtKB/TrEMBL
      A0A178VI77, A0A5S9XLM2
      Conserved Domains (1) summary
      cd01276
      Location:35 → 139
      PKCI_related; Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GUN2.1

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