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    NIC1 nicotinamidase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816789, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NIC1
    Official Full Name
    nicotinamidase 1
    Primary source
    TAIR:AT2G22570
    Locus tag
    AT2G22570
    See related
    Araport:AT2G22570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    A. THALIANA NICOTINAMIDASE 1; ATNIC1; F14M13.1; NIC2; nicotinamidase 1
    Summary
    encodes a nicotinamidase that converts nicotinamide into nicotinic acid. As such the encoded enzyme is involved in the pyridine nucleotide salvage pathway which may be connected to the de novo NAD biosynthesis through the ABA signaling pathway.
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    Genomic context

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    See NIC1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    5
    Sequence:
    Chromosome: 2; NC_003071.7 (9589435..9590932, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene K-box region and MADS-box transcription factor family protein Neighboring gene Kinase interacting (KIP1-like) family protein Neighboring gene tRNA-Ala Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nicotinamidase participates in the salvage pathway of NAD biosynthesis in Arabidopsis. Wang G, et al. Plant J, 2007 Mar. PMID 17335512
    2. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_127823.3
    NM_201782.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables nicotinamidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nicotinamidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within pyridine nucleotide salvage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    nicotinamidase 1
    NP_565539.1
    • nicotinamidase 1 (NIC1); CONTAINS InterPro DOMAIN/s: Isochorismatase-like (InterPro:IPR000868); Has 1180 Blast hits to 1180 proteins in 562 species: Archae - 22; Bacteria - 1075; Metazoa - 0; Fungi - 0; Plants - 49; Viruses - 0; Other Eukaryotes - 34 (source: NCBI BLink).
    NP_973511.1
    • nicotinamidase 1 (NIC1); CONTAINS InterPro DOMAIN/s: Isochorismatase-like (InterPro:IPR000868); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      9589435..9590932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127823.3 → NP_565539.1  nicotinamidase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565539.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IJK3, Q8LFK8, Q8S8F9, Q9ZQ55
      UniProtKB/TrEMBL
      A0A178VQ19, A0A5S9X084
      Conserved Domains (1) summary
      PLN02743
      Location:3 → 242
      PLN02743; nicotinamidase

    2. NM_201782.3 → NP_973511.1  nicotinamidase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973511.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8S8F9
      Conserved Domains (1) summary
      cl00220
      Location:3 → 157
      cysteine_hydrolases; Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8S8F9.1

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