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    BHLH100 basic helix-loop-helix protein 100 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818723, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BHLH100
    Official Full Name
    basic helix-loop-helix protein 100
    Primary source
    TAIR:AT2G41240
    Locus tag
    AT2G41240
    See related
    Araport:AT2G41240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    basic helix-loop-helix protein 100; F13H10.21; F13H10_21
    Summary
    Encodes a member of the basic helix-loop-helix transcription factor family protein. Functions as a key regulator of iron-deficiency responses independent of the master regulator FIT. Likely regulates genes involved in the distribution of iron within the plant.
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    Genomic context

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    See BHLH100 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    2
    Sequence:
    Chromosome: 2; NC_003071.7 (17198037..17199454, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ORGAN SIZE-like protein Neighboring gene Haloacid dehalogenase-like hydrolase (HAD) superfamily protein Neighboring gene glycine-rich protein / late embryogenesis abundant protein (M17)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Iron deficiency-induced transcription factors bHLH38/100/101 negatively modulate flowering time in Arabidopsis thaliana. Chen W, et al. Plant Sci, 2021 Jul. PMID 34034877
    2. Arabidopsis bHLH100 and bHLH101 control iron homeostasis via a FIT-independent pathway. Sivitz AB, et al. PLoS One, 2012. PMID 22984573, Free PMC Article
    3. Iron deficiency-mediated stress regulation of four subgroup Ib BHLH genes in Arabidopsis thaliana. Wang HY, et al. Planta, 2007 Sep. PMID 17516080
    4. Requirement and functional redundancy of Ib subgroup bHLH proteins for iron deficiency responses and uptake in Arabidopsis thaliana. Wang N, et al. Mol Plant, 2013 Mar. PMID 22983953
    5. The relationship of drought-related gene expression in Arabidopsis thaliana to hormonal and environmental factors. Huang D, et al. J Exp Bot, 2008. PMID 18552355, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Iron deficiency-induced transcription factors bHLH38/100/101 negatively modulate flowering time in Arabidopsis thaliana.
      Title: Iron deficiency-induced transcription factors bHLH38/100/101 negatively modulate flowering time in Arabidopsis thaliana.
    2. bHLH100 and bHLH101 are key regulators of iron-deficiency responses independent of the master regulator FIT
      Title: Arabidopsis bHLH100 and bHLH101 control iron homeostasis via a FIT-independent pathway.
    3. up-regulated by iron deficiency in roots and leaves
      Title: Iron deficiency-mediated stress regulation of four subgroup Ib BHLH genes in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_129689.2
    NM_180018.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to iron ion starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    basic helix-loop-helix protein 100
    NP_181657.1
    • basic helix-loop-helix protein 100 (BHLH100); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: response to water deprivation, regulation of transcription; LOCATED IN: nucleus; CONTAINS InterPro DOMAIN/s: Achaete-scute transcription factor related (InterPro:IPR015660), Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT3G56970.1); Has 1014 Blast hits to 1014 proteins in 111 species: Archae - 0; Bacteria - 2; Metazoa - 217; Fungi - 10; Plants - 760; Viruses - 12; Other Eukaryotes - 13 (source: NCBI BLink).
    NP_850349.1
    • basic helix-loop-helix protein 100 (BHLH100); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: response to water deprivation, regulation of transcription; LOCATED IN: nucleus; CONTAINS InterPro DOMAIN/s: Achaete-scute transcription factor related (InterPro:IPR015660), Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT3G56970.1); Has 850 Blast hits to 850 proteins in 99 species: Archae - 0; Bacteria - 2; Metazoa - 130; Fungi - 33; Plants - 678; Viruses - 0; Other Eukaryotes - 7 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      17198037..17199454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129689.2 → NP_181657.1  basic helix-loop-helix protein 100 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181657.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3E7M6, Q9ZVB5
      UniProtKB/TrEMBL
      A0A178VX33, A0A384LFW4, C0SV82
      Conserved Domains (1) summary
      cd18914
      Location:62 → 136
      bHLH_AtORG2_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana OBP3-responsive gene 2 (ORG2), 3 (ORG3) and similar proteins

    2. NM_180018.1 → NP_850349.1  basic helix-loop-helix protein 100 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850349.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZVB5
      Conserved Domains (1) summary
      pfam00010
      Location:62 → 113
      HLH; Helix-loop-helix DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZVB5.1

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