EBP ethylene-responsive element binding protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: EBP
Official Full Name: ethylene-responsive element binding protein
Primary source: TAIR:AT3G16770
Locus tag: AT3G16770
See related: Araport:AT3G16770
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATEBP; ERF72; ETHYLENE RESPONSE FACTOR 72; ethylene-responsive element binding protein; MGL6.1; RAP2.3; RELATED TO AP2 3
Summary: Encodes a member of the ERF (ethylene response factor) subfamily B-2 of the plant specific ERF/AP2 transcription factor family (RAP2.3). The protein contains one AP2 domain. There are 5 members in this subfamily including RAP2.2 AND RAP2.12.It is localized to the nucleus and acts as a transcriptional activator through the GCC-box. It has been identified as a suppressor of Bax-induced cell death by functional screening in yeast and can also suppress Bax-induced cell death in tobacco plants. Overexpression of this gene in tobacco BY-2 cells confers resistance to H2O2 and heat stresses. Overexpression in Arabidopsis causes upregulation of PDF1.2 and GST6. It is part of the ethylene signaling pathway and is predicted to act downstream of EIN2 and CTR1, but not under EIN3.
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Genomic context

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See EBP in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 2

Sequence:: Chromosome: 3; NC_003074.8 (5705541..5707084)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RAP2.3 negatively regulates nitric oxide biosynthesis and related responses through a rheostat-like mechanism in Arabidopsis.
Title: RAP2.3 negatively regulates nitric oxide biosynthesis and related responses through a rheostat-like mechanism in Arabidopsis.
found that hypocotyl cell elongation is regulated by a network involving ethylene, auxin, and BR signalling, which is mediated by interactions among ERF72, ARF6, and BZR1. ERF72 interacted directly with ARF6 and BZR1 in vitro and in vivo, and it antagonised regulation by ARF6 and BZR1 of the transcription of BEE3 and XTH7
Title: ERF72 interacts with ARF6 and BZR1 to regulate hypocotyl elongation in Arabidopsis.
RAP2.2, RAP2.3 and RAP2.12 play a role in modulating oxidative and osmotic stress tolerance during submergence acclimation.
Title: The low oxygen, oxidative and osmotic stress responses synergistically act through the ethylene response factor VII genes RAP2.12, RAP2.2 and RAP2.3.
AtEB domains bind to a target DNA motif with a universal CG step core recognition and different flanking bases preference
Title: Four divergent Arabidopsis ethylene-responsive element-binding factor domains bind to a target DNA motif with a universal CG step core recognition and different flanking bases preference.
Interaction of acyl-CoA-binding protein 4 with the ethylene-responsive element binding protein is induced by ethylene.
Title: Ethylene- and pathogen-inducible Arabidopsis acyl-CoA-binding protein 4 interacts with an ethylene-responsive element binding protein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_112550.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within ethylene-activated signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within heat acclimation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to cytokinin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to ethylene	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethylene	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to jasmonic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nitrate starvation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to other organism	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ethylene-responsive element binding protein

NP_188299.1

ethylene-responsive element binding protein (EBP); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: Integrase-type DNA-binding superfamily protein (TAIR:AT2G47520.1); Has 5957 Blast hits to 5752 proteins in 250 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 5929; Viruses - 4; Other Eukaryotes - 24 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

5705541..5707084

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_112550.5 → NP_188299.1 ethylene-responsive element binding protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_188299.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O04382, O23105, P42736

UniProtKB/TrEMBL

A0A5S9XEB1, A0A654F7W0, A0A7G2ENB6

Conserved Domains (1) summary

smart00380
Location:79 → 135

AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs