U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ABF2 abscisic acid responsive elements-binding factor 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841095, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ABF2
    Official Full Name
    abscisic acid responsive elements-binding factor 2
    Primary source
    TAIR:AT1G45249
    Locus tag
    AT1G45249
    See related
    Araport:AT1G45249
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    abscisic acid responsive elements-binding factor 2; ABSCISIC ACID RESPONSIVE ELEMENTS-BINDING PROTEIN 2; AREB1; AtABF2; ATAREB1
    Summary
    Leucine zipper transcription factor that binds to the abscisic acid (ABA)#Aeiresponsive element (ABRE) motif in the promoter region of ABA-inducible genes. Enhances drought tolerance in vegetative tissues. Required for normal glucose response. Localized in the nucleus. Expressed constitutively in roots, leaf vascular tissues, and hydathodes or in all tissues under stress conditions. It's phosphorylated by a ABA-activated 42-KDa kinase. Overexpression of the phosphorylated active form of AREB1 expressed many ABA-inducible genes, such as RD29B, without ABA treatment.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ABF2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (17165125..17167924, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene tRNA-Pro Neighboring gene Nucleolar histone methyltransferase-related protein Neighboring gene DCL protein (DUF3223) Neighboring gene Translation elongation factor EFG/EF2 protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Constitutive expression of Arabidopsis bZIP transcription factor AREB1 activates cross-signaling responses in soybean under drought and flooding stresses. Fuhrmann-Aoyagi MB, et al. J Plant Physiol, 2021 Feb. PMID 33401097
    2. Transcriptional modulation of AREB-1 by CRISPRa improves plant physiological performance under severe water deficit. de Melo BP, et al. Sci Rep, 2020 Oct 1. PMID 33004844, Free PMC Article
    3. Trehalose-6-phosphate phosphatase E modulates ABA-controlled root growth and stomatal movement in Arabidopsis. Wang W, et al. J Integr Plant Biol, 2020 Oct. PMID 32167237, Free PMC Article
    4. Deeply diverged alleles in the Arabidopsis AREB1 transcription factor drive genome-wide differences in transcriptional response to the environment. Des Marais DL, et al. Mol Biol Evol, 2015 Apr. PMID 25540452
    5. AREB1 is a transcription activator of novel ABRE-dependent ABA signaling that enhances drought stress tolerance in Arabidopsis. Fujita Y, et al. Plant Cell, 2005 Dec. PMID 16284313, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Constitutive expression of Arabidopsis bZIP transcription factor AREB1 activates cross-signaling responses in soybean under drought and flooding stresses.
      Title: Constitutive expression of Arabidopsis bZIP transcription factor AREB1 activates cross-signaling responses in soybean under drought and flooding stresses.
    2. Transcriptional modulation of AREB-1 by CRISPRa improves plant physiological performance under severe water deficit.
      Title: Transcriptional modulation of AREB-1 by CRISPRa improves plant physiological performance under severe water deficit.
    3. ABF2, ABF3, and ABF4 Promote ABA-Mediated Chlorophyll Degradation and Leaf Senescence by Transcriptional Activation of Chlorophyll Catabolic Genes and Senescence-Associated Genes in Arabidopsis
      Title: ABF2, ABF3, and ABF4 Promote ABA-Mediated Chlorophyll Degradation and Leaf Senescence by Transcriptional Activation of Chlorophyll Catabolic Genes and Senescence-Associated Genes in Arabidopsis.
    4. The role of AREB1 in salt stress response: AREB1 expression is regulated by NAP in salt stress response
      Title: Arabidopsis AtNAP functions as a negative regulator via repression of AREB1 in salt stress response.
    5. 2 intermediate-frequency haplotype variants at AREB1 were characterized. These variants drive differences in gene regulatory network response to environmental cues and may play an important role in environmental adaptation.
      Title: Deeply diverged alleles in the Arabidopsis AREB1 transcription factor drive genome-wide differences in transcriptional response to the environment.
    6. ABF2 interacts with DREB2C, DREB2A, and DREB1A.
      Title: DREB2C interacts with ABF2, a bZIP protein regulating abscisic acid-responsive gene expression, and its overexpression affects abscisic acid sensitivity.
    7. AREB1, AREB2, and ABF3 are master transcription factors that regulate the ABRE-dependent expression of water-stress responsive genes in ABA signaling in response to water stresses in a cooperative manner.
      Title: AREB1, AREB2, and ABF3 are master transcription factors that cooperatively regulate ABRE-dependent ABA signaling involved in drought stress tolerance and require ABA for full activation.
    8. abscisic acid-dependent multisite phosphorylation of AREB1 regulates its own activation in plants
      Title: Abscisic acid-dependent multisite phosphorylation regulates the activity of a transcription activator AREB1.
    9. bZIP proteins interacting with the ABA-responsive elements, is involved in Absicic acid/stress responses in arabidopsis.[ABF2]
      Title: ABF2, an ABRE-binding bZIP factor, is an essential component of glucose signaling and its overexpression affects multiple stress tolerance.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_001198228.1
    NM_001333255.1
    NM_001333256.1
    NM_001333257.1
    NM_001333258.1
    NM_001333259.1
    NM_001333260.1
    NM_001333261.1
    NM_179446.5
    NM_202252.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within glucose mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    abscisic acid responsive elements-binding factor 2
    NP_001185157.1
    • abscisic acid responsive elements-binding factor 2 (ABF2); CONTAINS InterPro DOMAIN/s: Basic-leucine zipper (bZIP) transcription factor (InterPro:IPR004827), Basic leucine zipper (InterPro:IPR011700); BEST Arabidopsis thaliana protein match is: abscisic acid responsive elements-binding factor 3 (TAIR:AT4G34000.2).
    NP_001319166.1
    • abscisic acid responsive elements-binding factor 2 (ABF2); FUNCTIONS IN: protein binding, DNA binding, transcription activator activity, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 6 processes; LOCATED IN: nucleus; EXPRESSED IN: hydathode, leaf vascular system, whole plant, root, cultured cell; CONTAINS InterPro DOMAIN/s: Basic-leucine zipper (bZIP) transcription factor (InterPro:IPR004827); BEST Arabidopsis thaliana protein match is: abscisic acid responsive element-binding factor 1 (TAIR:AT1G49720.2); Has 532 Blast hits to 413 proteins in 48 species: Archae - 0; Bacteria - 11; Metazoa - 7; Fungi - 4; Plants - 509; Viruses - 0; Other Eukaryotes - 1 (source: NCBI BLink).
    NP_849777.1
    • abscisic acid responsive elements-binding factor 2 (ABF2); FUNCTIONS IN: protein binding, DNA binding, transcription activator activity, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 6 processes; LOCATED IN: nucleus; EXPRESSED IN: hydathode, leaf vascular system, whole plant, root, cultured cell; CONTAINS InterPro DOMAIN/s: Basic-leucine zipper (bZIP) transcription factor (InterPro:IPR004827), bZIP transcription factor, bZIP-1 (InterPro:IPR011616); BEST Arabidopsis thaliana protein match is: abscisic acid responsive elements-binding factor 3 (TAIR:AT4G34000.2); Has 2346 Blast hits to 2224 proteins in 173 species: Archae - 0; Bacteria - 11; Metazoa - 428; Fungi - 29; Plants - 1792; Viruses - 0; Other Eukaryotes - 86 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      17165125..17167924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179446.5 → NP_849777.1  abscisic acid responsive elements-binding factor 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849777.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M7Q4
      UniProtKB/TrEMBL
      A0A178W527, A0A7G2E0X3
      Conserved Domains (1) summary
      cd14707
      Location:338 → 392
      bZIP_plant_BZIP46; Basic leucine zipper (bZIP) domain of uncharaterized Plant BZIP transcription factors: a DNA-binding and dimerization domain

    2. NM_001333258.1 → NP_001322814.1  abscisic acid responsive elements-binding factor 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W5I5, A0A1P8AV67

    3. NM_001333256.1 → NP_001319166.1  abscisic acid responsive elements-binding factor 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W5I5, F4HRD0

    4. NM_001333257.1 → NP_001322813.1  abscisic acid responsive elements-binding factor 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W5I5, F4HRD0

    5. NM_001333259.1 → NP_001322815.1  abscisic acid responsive elements-binding factor 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W527, A0A1P8AV75

    6. NM_001333260.1 → NP_001322811.1  abscisic acid responsive elements-binding factor 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W527, A0A1P8AV75

    7. NM_001198228.1 → NP_001185157.1  abscisic acid responsive elements-binding factor 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185157.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W527, F4HRC9
      Conserved Domains (1) summary
      cd14707
      Location:338 → 403
      bZIP_plant_BZIP46; Basic leucine zipper (bZIP) domain of uncharaterized Plant BZIP transcription factors: a DNA-binding and dimerization domain

    8. NM_001333261.1 → NP_001322812.1  abscisic acid responsive elements-binding factor 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W5I5, F4HRD0

    9. NM_001333255.1 → NP_001322816.1  abscisic acid responsive elements-binding factor 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W5I5, A0A1P8AV67

    10. NM_202252.3 → NP_973981.2  abscisic acid responsive elements-binding factor 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973981.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W5I5, F4HRD0
      Conserved Domains (1) summary
      cd14707
      Location:338 → 390
      bZIP_plant_BZIP46; Basic leucine zipper (bZIP) domain of uncharaterized Plant BZIP transcription factors: a DNA-binding and dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M7Q4.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools