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    FBH3 basic helix-loop-helix (bHLH) DNA-binding superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841537, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FBH3
    Official Full Name
    basic helix-loop-helix (bHLH) DNA-binding superfamily protein
    Primary source
    TAIR:AT1G51140
    Locus tag
    AT1G51140
    See related
    Araport:AT1G51140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ABA-responsive kinase substrate 1; AKS1; F23H24.3; F23H24_3; FLOWERING BHLH 3
    Summary
    Encodes a basic helix?loop?helix-type transcription factor involved in photoperiodism flowering.
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    Genomic context

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    See FBH3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (18943447..18945812, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene AP2/B3 transcription factor family protein Neighboring gene Nse4, component of Smc5/6 DNA repair complex Neighboring gene DegP protease 6 Neighboring gene SNARE-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. bHLH122 is important for drought and osmotic stress resistance in Arabidopsis and in the repression of ABA catabolism. Liu W, et al. New Phytol, 2014 Mar. PMID 24261563
    2. Inhibition of the Arabidopsis bHLH transcription factor by monomerization through abscisic acid-induced phosphorylation. Takahashi Y, et al. Plant J, 2016 Sep. PMID 27227462
    3. CFLAP1 and CFLAP2 Are Two bHLH Transcription Factors Participating in Synergistic Regulation of AtCFL1-Mediated Cuticle Development in Arabidopsis. Li S, et al. PLoS Genet, 2016 Jan. PMID 26745719, Free PMC Article
    4. Reconstitution of Abscisic Acid Signaling from the Receptor to DNA via bHLH Transcription Factors. Takahashi Y, et al. Plant Physiol, 2017 Jun. PMID 28438792, Free PMC Article
    5. bHLH transcription factors that facilitate K⁺ uptake during stomatal opening are repressed by abscisic acid through phosphorylation. Takahashi Y, et al. Sci Signal, 2013 Jun 18. PMID 23779086

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AKS1 provides a link between the signaling complex and abscisic Acid-responsive genes.SnRK2.6 phosphorylates AKS1 in guard cells.
      Title: Reconstitution of Abscisic Acid Signaling from the Receptor to DNA via bHLH Transcription Factors.
    2. Phosphorylation results in the monomerization of AKS1 multimers and inhibits AKS1 binding to DNA. AKS1 forms homo-multimers which dissociate following phosphorylation.
      Title: Inhibition of the Arabidopsis bHLH transcription factor by monomerization through abscisic acid-induced phosphorylation.
    3. These results suggest that bHLH122 functions as a positive regulator of drought, sodium chloride and osmotic signaling.
      Title: bHLH122 is important for drought and osmotic stress resistance in Arabidopsis and in the repression of ABA catabolism.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_103993.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to abscisic acid stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cutin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within photoperiodism, flowering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of photoperiodism, flowering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect regulation of potassium ion import IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in regulation of stomatal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of stomatal movement IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect regulation of stomatal opening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to abscisic acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to osmotic stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to salt IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to salt IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    basic helix-loop-helix (bHLH) DNA-binding superfamily protein
    NP_564583.1
    • basic helix-loop-helix (bHLH) DNA-binding superfamily protein; FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT2G42280.1); Has 1835 Blast hits to 1829 proteins in 66 species: Archae - 0; Bacteria - 0; Metazoa - 1; Fungi - 5; Plants - 1818; Viruses - 0; Other Eukaryotes - 11 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      18943447..18945812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103993.3 → NP_564583.1  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564583.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C690
      UniProtKB/TrEMBL
      A0A178WHN7, A0A5S9WL93, A0A7G2E1Z1
      Conserved Domains (1) summary
      cd11393
      Location:315 → 368
      bHLH_AtbHLH_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription factors and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C690.1

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