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    FU kinase family with ARM repeat domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841446, updated on 18-Sep-2024

    Summary

    Official Symbol
    FU
    Official Full Name
    kinase family with ARM repeat domain-containing protein
    Primary source
    TAIR:AT1G50240
    Locus tag
    AT1G50240
    See related
    Araport:AT1G50240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    FUSED
    Summary
    The FUSED (FU) gene belongs to Ser/Thr protein kinase family and has a key role in the hedgehog signaling pathway known to control cell proliferation and patterning in fruit flies and humans . Arabidopsis thaliana genome has a single Fu gene. Cytokinesis-defective mutants, which we named two-in-one (tio), result from mutations in Arabidopsis Fu. Phenotypic analysis of tio mutants reveals an essential role for TIO in conventional modes of cytokinesis in plant meristems and during male gametogenesis. TIO is tightly localized to the midline of the nascent phragmoplast and remains associated with the expanding phragmoplast ring. This gene was previously annotated as two gene models, AT1G50230.1 and AT1G50240.1, however the experimental evidence exists (Oh et al, Current Biology, 2005) showing that these two models are in fact single gene, named FUSED.
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    Genomic context

    Location:
    chromosome: 1
    Exon count:
    23
    Sequence:
    Chromosome: 1; NC_003070.9 (18606511..18614500)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene B3 domain protein Neighboring gene FTSH protease 1 Neighboring gene N-terminal-transmembrane-C2 domain type 5.1 Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Phototropic-responsive NPH3 family protein

    Interactions

    General gene information

    NM_001333427.1
    NM_001333428.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinesin binding PubMed 
    enables protein binding PubMed 
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    Component Evidence Code Pubs
    located_in nucleus  
    located_in phragmoplast PubMed 

    General protein information

    Preferred Names
    kinase family with ARM repeat domain-containing protein
    NP_001319189.1
    • FUSED (FU); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), 26S proteasome non-ATPase regulatory subunit 5 (InterPro:IPR019538), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: serine/threonine protein kinase 2 (TAIR:AT3G08720.2); Has 138334 Blast hits to 135590 proteins in 4834 species: Archae - 164; Bacteria - 15793; Metazoa - 51363; Fungi - 13983; Plants - 33508; Viruses - 544; Other Eukaryotes - 22979 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      18606511..18614500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001333427.1 → NP_001319189.1  kinase family with ARM repeat domain-containing protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2QAV0, Q2QB51, Q9SX42
      UniProtKB/TrEMBL
      A0A178WC55, A0A5S9WQG3
    2. NM_001333428.1 → NP_001321239.1  kinase family with ARM repeat domain-containing protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2QAV0, Q2QB51, Q9SX42
      UniProtKB/TrEMBL
      A0A178WC55, A0A5S9WQG3
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