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    TED3 Pex2/Pex12 N-terminal domain-containing protein / zinc finger (C3HC4-type RING finger) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844320, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TED3
    Official Full Name
    Pex2/Pex12 N-terminal domain-containing protein / zinc finger (C3HC4-type RING finger) family protein
    Primary source
    TAIR:AT1G79810
    Locus tag
    AT1G79810
    See related
    Araport:AT1G79810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS PEROXIN 2; ATPEX2; F20B17.23; F20B17_23; PEROXIN 2; PEX2; PEX2P; REVERSAL OF THE DET PHENOTYPE 3
    Summary
    Dominant suppressor of det1 phenotypes. Encodes a peroxisomal protein essential for Arabidopsis growth. Inserted directly from the cytosol into peroxisomes.
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    Genomic context

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    See TED3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (30019744..30022486)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein family (UPF0497) Neighboring gene Haloacid dehalogenase-like hydrolase (HAD) superfamily protein Neighboring gene early nodulin-like protein 7 Neighboring gene ncRNA Neighboring gene Major facilitator superfamily protein Neighboring gene ncRNA Neighboring gene golgin Putative 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A role for peroxisomes in photomorphogenesis and development of Arabidopsis. Hu J, et al. Science, 2002 Jul 19. PMID 12130786
    2. Extragenic suppressors of the Arabidopsis det1 mutant identify elements of flowering-time and light-response regulatory pathways. Pepper AE, et al. Genetics, 1997 Apr. PMID 9093863, Free PMC Article
    3. AtPEX2 and AtPEX10 are targeted to peroxisomes independently of known endoplasmic reticulum trafficking routes. Sparkes IA, et al. Plant Physiol, 2005 Oct. PMID 16169966, Free PMC Article
    4. Ectopic expression of the RING domain of the Arabidopsis peroxin2 protein partially suppresses the phenotype of the photomorphogenic mutant de-etiolated1. Desai M, et al. PLoS One, 2014. PMID 25248106, Free PMC Article
    5. Peroxisomal ubiquitin-protein ligases peroxin2 and peroxin10 have distinct but synergistic roles in matrix protein import and peroxin5 retrotranslocation in Arabidopsis. Burkhart SE, et al. Plant Physiol, 2014 Nov. PMID 25214533, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. When fused with a fluorescent protein and overexpressed, the PEX2 RING domain can localize to the nucleus, where it is able to interact with HY5, and PEX2 RING domain overexpression in det1 also partially suppresses the det1 phenotype.
      Title: Ectopic expression of the RING domain of the Arabidopsis peroxin2 protein partially suppresses the phenotype of the photomorphogenic mutant de-etiolated1.
    2. PEX2 and PEX10 cooperate to support import of matrix proteins into plant peroxisomes and peroxin5 retrotranslocation in Arabidopsis.
      Title: Peroxisomal ubiquitin-protein ligases peroxin2 and peroxin10 have distinct but synergistic roles in matrix protein import and peroxin5 retrotranslocation in Arabidopsis.
    3. Data show that formation of glyoxysomal reticulum seemed to be impaired in PEX10-DeltaZn but not in PEX2-DeltaZn-T7 or PEX12-DeltaZn-T7 plants.
      Title: Different functions of the C3HC4 zinc RING finger peroxins PEX10, PEX2, and PEX12 in peroxisome formation and matrix protein import.
    4. PEX2 and PEX10 are inserted into peroxisome membranes directly from the cytosol.
      Title: AtPEX2 and AtPEX10 are targeted to peroxisomes independently of known endoplasmic reticulum trafficking routes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_106630.3
    NM_202454.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within peroxisome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within photomorphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into peroxisome matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein import into peroxisome matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein monoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    Pex2/Pex12 N-terminal domain-containing protein / zinc finger (C3HC4-type RING finger) family protein
    NP_565222.1
    • REVERSAL OF THE DET PHENOTYPE 3 (TED3); FUNCTIONS IN: zinc ion binding; INVOLVED IN: protein import into peroxisome matrix, fatty acid beta-oxidation, peroxisome organization, photomorphogenesis; LOCATED IN: cytosol, peroxisome; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Pex, N-terminal (InterPro:IPR006845), Zinc finger, RING-type (InterPro:IPR001841); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_974183.1
    • REVERSAL OF THE DET PHENOTYPE 3 (TED3); FUNCTIONS IN: zinc ion binding; INVOLVED IN: protein import into peroxisome matrix, fatty acid beta-oxidation, peroxisome organization, photomorphogenesis; LOCATED IN: cytosol, peroxisome; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Pex, N-terminal (InterPro:IPR006845), Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      30019744..30022486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_202454.2 → NP_974183.1  Pex2/Pex12 N-terminal domain-containing protein / zinc finger (C3HC4-type RING finger) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974183.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WL96, F4HQB1
      Conserved Domains (2) summary
      cd00162
      Location:225 → 270
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam04757
      Location:1 → 191
      Pex2_Pex12; Pex2 / Pex12 amino terminal region

    2. NM_106630.3 → NP_565222.1  Pex2/Pex12 N-terminal domain-containing protein / zinc finger (C3HC4-type RING finger) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565222.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LFI7, Q9CA86, Q9M9Z9
      UniProtKB/TrEMBL
      A0A5S9WVV5, A0A654ES43
      Conserved Domains (2) summary
      cd16526
      Location:276 → 318
      RING-HC_PEX2; RING finger, HC subclass, found in peroxin-2 (PEX2) and similar proteins
      pfam04757
      Location:49 → 242
      Pex2_Pex12; Pex2 / Pex12 amino terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CA86.1

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