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    l(2)37Bb lethal (2) 37Bb [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49427, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(2)37Bbprovided by FlyBase
    Official Full Name
    lethal (2) 37Bbprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002021
    Locus tag
    Dmel_CG10655
    See related
    AllianceGenome:FB:FBgn0002021
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Bb; CG10655; dFOXRED1; Dmel\CG10655; l(2)35B2; l(2)E58
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Is active in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval fat body; embryonic/larval midgut; embryonic/larval midgut primordium; and larval muscle cell. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 19. Orthologous to human FOXRED1 (FAD dependent oxidoreductase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(2)37Bb in Genome Data Viewer
    Location:
    37B12-37B12; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19049843..19051612, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19049843..19051612, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Catecholamines up Neighboring gene Tetratricopeptide repeat domain 19 Neighboring gene Acinus Neighboring gene uncharacterized protein Neighboring gene Regulatory particle non-ATPase 3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural genetic variation in a dopamine receptor is associated with variation in female fertility in Drosophila melanogaster. Lyman RF, et al. Proc Biol Sci, 2023 Apr 12. PMID 37040806, Free PMC Article
    2. A diphenol oxidase gene is part of a cluster of genes involved in catecholamine metabolism and sclerotization in Drosophila. II. Molecular localization of the Dox-A2 coding region. Pentz ES, et al. Genetics, 1986 Apr. PMID 3007281, Free PMC Article
    3. Molecular mapping of a gene cluster flanking the Drosophila Dopa decarboxylase gene. Gilbert D, et al. Genetics, 1984 Apr. PMID 6425116, Free PMC Article
    4. The genetics of dopa decarboxylase in Drosophila melanogaster. IV. The genetics and cytology of the 37B10-37D1 region. Wright TR, et al. Chromosoma, 1981. PMID 6790250
    5. Effects of Ddc cluster lethal alleles on ovary growth, attachment, and egg production in Drosophila. McCrady E, et al. J Exp Zool, 1994 May 1. PMID 8176361

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lethal (2) 37Bb
    Names
    CG10655-PA
    l(2)37Bb-PA
    NP_536791.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19049843..19051612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080530.3 → NP_536791.1  lethal (2) 37Bb [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_536791.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJ10
      Related
      FBpp0080719
      Conserved Domains (1) summary
      COG0665
      Location:113 → 501
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJ10 Q9VJ10

    Gene LinkOut

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