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    Dtd D-aminoacyl-tRNA deacylase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41371, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dtdprovided by FlyBase
    Official Full Name
    D-aminoacyl-tRNA deacylaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037898
    Locus tag
    Dmel_CG18643
    See related
    AllianceGenome:FB:FBgn0037898
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18643; DmDTD; Dmel\CG18643; DTD
    Summary
    Enables Gly-tRNA(Ala) hydrolase activity. Predicted to be involved in tRNA metabolic process. Predicted to be active in cytoplasm. Orthologous to human DTD1 (D-aminoacyl-tRNA deacylase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dtd in Genome Data Viewer
    Location:
    86E5-86E5; 3-51 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11430061..11430762)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7255783..7256484)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ninaG Neighboring gene Spastizin Neighboring gene Ribosomal protein L24-like Neighboring gene uncharacterized protein Neighboring gene Exonuclease 3'-5' domain-containing 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Elongation Factor Tu Prevents Misediting of Gly-tRNA(Gly) Caused by the Design Behind the Chiral Proofreading Site of D-Aminoacyl-tRNA Deacylase. Routh SB, et al. PLoS Biol, 2016 May. PMID 27224426, Free PMC Article
    2. Role of D-aminoacyl-tRNA deacylase beyond chiral proofreading as a cellular defense against glycine mischarging by AlaRS. Pawar KI, et al. Elife, 2017 Mar 31. PMID 28362257, Free PMC Article
    3. Analysis of the Otd-dependent transcriptome supports the evolutionary conservation of CRX/OTX/OTD functions in flies and vertebrates. Ranade SS, et al. Dev Biol, 2008 Mar 15. PMID 18241855, Free PMC Article
    4. Ultra-deep sequencing of ribosome-associated poly-adenylated RNA in early Drosophila embryos reveals hundreds of conserved translated sORFs. Li H, et al. DNA Res, 2016 Dec. PMID 27559081, Free PMC Article
    5. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables D-aminoacyl-tRNA deacylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-tyrosyl-tRNA(Tyr) deacylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Gly-tRNA(Ala) hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    D-aminoacyl-tRNA deacylase
    Names
    CG18643-PB
    CG18643-PC
    Dtd-PB
    Dtd-PC
    NP_001287286.1
    NP_650072.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11430061..11430762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300357.1 → NP_001287286.1  D-aminoacyl-tRNA deacylase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287286.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LH54
      Conserved Domains (1) summary
      cl00253
      Location:2 → 45
      Dtyr_deacylase; D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not ...

    2. NM_141815.2 → NP_650072.2  D-aminoacyl-tRNA deacylase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650072.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4V4U7, Q4V6L2, Q9VGP0
      Conserved Domains (1) summary
      pfam02580
      Location:2 → 145
      Tyr_Deacylase; D-Tyr-tRNA(Tyr) deacylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LH54 A0A0B4LH54
    Q9VGP0.2 Q9VGP0

    Gene LinkOut

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