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    Stlk Ste20-like kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355135, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stlkprovided by FlyBase
    Official Full Name
    Ste20-like kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0046692
    Locus tag
    Dmel_CG40293
    See related
    AllianceGenome:FB:FBgn0046692
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD05623; CG40293; Dmel\CG40293; DmSTRADalpha; LD05623; stlk; STRADalpha
    Summary
    Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in positive regulation of TORC1 signaling. Predicted to be located in cytoplasm and nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in polyhydramnios, megalencephaly, and symptomatic epilepsy. Orthologous to several human genes including STRADB (STE20 related adaptor beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Stlk in Genome Data Viewer
    Location:
    41A3-41A3; 2-55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (4546691..4565281)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (434196..452786)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44100 Neighboring gene Ribosomal protein L38 Neighboring gene p120 catenin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation of LKB1 by PDK1 Inhibits Cell Proliferation and Organ Growth by Decreased Activation of AMPK. Borkowsky S, et al. Cells, 2023 Mar 6. PMID 36899949, Free PMC Article
    2. Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression. Dogliotti G, et al. Nat Commun, 2017 Jun 26. PMID 28649994, Free PMC Article
    3. Src42A is required for E-cadherin dynamics at cell junctions during Drosophila axis elongation. Chandran L, et al. Development, 2023 Jan 15. PMID 36628974
    4. Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component. Myster SH, et al. J Cell Biol, 2003 Feb 3. PMID 12551951, Free PMC Article
    5. RNA polymerase II kinetics in polo polyadenylation signal selection. Pinto PA, et al. EMBO J, 2011 May 20. PMID 21602789, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 4549714-4550518 mobile_element_type = transposon:H{}3283
    • Loc: 4552144-4552291 mobile_element_type = transposon:INE-1{}3153
    • Loc: 4552596-4557314 mobile_element_type = transposon:Doc2{}4272
    • Loc: 4557359-4557397 mobile_element_type = transposon:1360{}3632
    • Loc: 4558234-4558381 mobile_element_type = transposon:diver2{}3801
    • Loc: 4558467-4558946 mobile_element_type = transposon:X{}3139
    • Loc: 4559643-4560084 mobile_element_type = transposon:INE-1{}3166
    • Loc: 4561980-4562391 mobile_element_type = transposon:INE-1{}3168
    • Loc: 4563961-4564201 mobile_element_type = transposon:INE-1{}3172

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables protein kinase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    enables protein serine/threonine kinase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of TORC1 signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Ste20-like kinase
    Names
    CG40293-PA
    CG40293-PC
    Stlk-PA
    Stlk-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      4546691..4565281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042977.3 → NP_001036442.1  Ste20-like kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036442.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P83098, Q7PLH7, Q8T0F8
      UniProtKB/TrEMBL
      A0A0B4K7S5
      Conserved Domains (2) summary
      smart00220
      Location:10 → 298
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08216
      Location:7 → 312
      PK_STRAD; Pseudokinase domain of STE20-related kinase adapter protein

    2. NM_001259209.2 → NP_001246138.1  Ste20-like kinase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246138.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P83098, Q7PLH7, Q8T0F8
      UniProtKB/TrEMBL
      A0A0B4K7S5
      Conserved Domains (2) summary
      smart00220
      Location:10 → 298
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08216
      Location:7 → 312
      PK_STRAD; Pseudokinase domain of STE20-related kinase adapter protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7S5 A0A0B4K7S5
    P83098.2 P83098

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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