U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MrgBP MRG/MORF4L binding protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35880, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MrgBPprovided by FlyBase
    Official Full Name
    MRG/MORF4L binding proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033341
    Locus tag
    Dmel_CG13746
    See related
    AllianceGenome:FB:FBgn0033341
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13746; Dmel\CG13746; dMrgB; dMrgBP; MRGBP
    Summary
    Involved in DNA repair-dependent chromatin remodeling. Part of NuA4 histone acetyltransferase complex. Is expressed in organism. Used to study prostate cancer. Orthologous to human MRGBP (MRG domain binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MrgBP in Genome Data Viewer
    Location:
    44F3-44F3; 2-59 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8900566..8901375, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4788071..4788880, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Secretory 31 Neighboring gene antisense RNA:CR45202 Neighboring gene anastral spindle 2 Neighboring gene uncharacterized protein Neighboring gene G protein gamma subunit 1 Neighboring gene Chaperonin containing TCP1 subunit 8

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Myc and the Tip60 chromatin remodeling complex control neuroblast maintenance and polarity in Drosophila. Rust K, et al. EMBO J, 2018 Aug 15. PMID 29997178, Free PMC Article
    2. In and out: histone variant exchange in chromatin. Jin J, et al. Trends Biochem Sci, 2005 Dec. PMID 16257529
    3. Patterning chromatin: form and function for H2A.Z variant nucleosomes. Raisner RM, et al. Curr Opin Genet Dev, 2006 Apr. PMID 16503125
    4. Drosophila SWR1 and NuA4 complexes are defined by DOMINO isoforms. Scacchetti A, et al. Elife, 2020 May 20. PMID 32432549, Free PMC Article
    5. A genetic screen in Drosophila for regulators of human prostate cancer progression. Ito S, et al. Biochem Biophys Res Commun, 2014 Sep 5. PMID 25117438

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in DNA repair-dependent chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of H4/H2A histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    MRG/MORF4L binding protein
    Names
    CG13746-PA
    MrgBP-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8900566..8901375 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136573.4 → NP_610417.1  MRG/MORF4L binding protein [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610417.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K003
      Related
      FBpp0087765
      Conserved Domains (1) summary
      pfam07904
      Location:29 → 106
      Eaf7; Chromatin modification-related protein EAF7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K003 Q7K003

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools