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    KrT95D Krueppel target at 95D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42843, updated on 27-Dec-2024

    Summary

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    Official Symbol
    KrT95Dprovided by FlyBase
    Official Full Name
    Krueppel target at 95Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020647
    Locus tag
    Dmel_CG5405
    See related
    AllianceGenome:FB:FBgn0020647
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5405; Dmel\CG5405
    Summary
    Predicted to be involved in mitochondrion-endoplasmic reticulum membrane tethering and protein localization to plasma membrane. Predicted to be located in endoplasmic reticulum. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; larval muscle cell; and visceral trunk mesoderm derivative. Human ortholog(s) of this gene implicated in Schuurs-Hoeijmakers Syndrome and developmental and epileptic encephalopathy 66. Orthologous to several human genes including PACS2 (phosphofurin acidic cluster sorting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See KrT95D in Genome Data Viewer
    Location:
    95D5-95D8; 3-82 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23997538..24031827, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19823260..19857549, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rab7 Neighboring gene uncharacterized protein Neighboring gene Like Sm 3 Neighboring gene Methyltransferase like 3 Neighboring gene Mitochondrial Rho Neighboring gene spastin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Putative Krüppel target gene of novel sequence expressed in Drosophila VO5 muscle precursors. Hartmann C, et al. Dev Genes Evol, 1997 Aug. PMID 27747416
    2. Drosophila Inducer of MEiosis 4 (IME4) is required for Notch signaling during oogenesis. Hongay CF, et al. Proc Natl Acad Sci U S A, 2011 Sep 6. PMID 21873203, Free PMC Article
    3. DDX17 is involved in DNA damage repair and modifies FUS toxicity in an RGG-domain dependent manner. Fortuna TR, et al. Acta Neuropathol, 2021 Sep. PMID 34061233, Free PMC Article
    4. Parallel and population-specific gene regulatory evolution in cold-adapted fly populations. Huang Y, et al. Genetics, 2021 Jul 14. PMID 33989401, Free PMC Article
    5. MidExDB: a database of Drosophila CNS midline cell gene expression. Wheeler SR, et al. BMC Dev Biol, 2009 Nov 10. PMID 19903351, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrion-endoplasmic reticulum membrane tethering ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    krueppel target at 95D
    Names
    CG5405-PA
    CG5405-PB
    CG5405-PC
    CG5405-PD
    CG5405-PF
    KrT95D-PA
    KrT95D-PB
    KrT95D-PC
    KrT95D-PD
    KrT95D-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23997538..24031827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170110.4 → NP_732935.2  krueppel target at 95D, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732935.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRS5
      Conserved Domains (1) summary
      pfam10254
      Location:634 → 1125
      Pacs-1; PACS-1 cytosolic sorting protein

    2. NM_079749.6 → NP_524473.2  krueppel target at 95D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524473.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCE7
      Related
      FBpp0083895
      Conserved Domains (1) summary
      pfam10254
      Location:676 → 1167
      Pacs-1; PACS-1 cytosolic sorting protein

    3. NM_170108.4 → NP_732933.1  krueppel target at 95D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732933.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCE7
      Related
      FBpp0083894
      Conserved Domains (1) summary
      pfam10254
      Location:676 → 1167
      Pacs-1; PACS-1 cytosolic sorting protein

    4. NM_001170238.2 → NP_001163709.2  krueppel target at 95D, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163709.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRS5
      Conserved Domains (1) summary
      pfam10254
      Location:634 → 1125
      Pacs-1; PACS-1 cytosolic sorting protein

    5. NM_170109.2 → NP_732934.2  krueppel target at 95D, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732934.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18359, Q95R71
      Conserved Domains (1) summary
      pfam10254
      Location:343 → 834
      Pacs-1; PACS-1 cytosolic sorting protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18359 O18359
    Q8MRS5 Q8MRS5
    Q95R71 Q95R71
    Q9VCE7 Q9VCE7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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