lwr lesswright [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: lwrprovided by FlyBase
Official Full Name: lesswrightprovided by FlyBase
Primary source: FLYBASE:FBgn0010602
Locus tag: Dmel_CG3018
See related: AllianceGenome:FB:FBgn0010602
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3018; dip4; Dmel\CG3018; Dmubc9; DmUbc9; dUbc9; dUBC9; DUbc9; FBgn0010602; hbl; i105; i56; Iwr; l(2)01519; l(2)02858; l(2)05486; l(2)05487; Lwr; semi; Ubc 9; Ubc-9; ubc9; Ubc9; UBC9; Ubc9/Lwr; UbcD9
Summary: Enables SUMO conjugating enzyme activity; heat shock protein binding activity; and ubiquitin activating enzyme binding activity. Involved in several processes, including negative regulation of hemocyte proliferation; regulation of gene expression; and regulation of signal transduction. Located in condensed chromosome, centromeric region and nucleus. Part of outer kinetochore. Is expressed in several structures, including adult head; cortical zone of lymph gland primary lobe; embryonic/larval dorsal vessel; germarium; and germline cell. Used to study hematologic cancer. Orthologous to human UBE2I (ubiquitin conjugating enzyme E2 I). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 21E2-21E2; 2-1.5 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (540599..542580, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (540599..542580, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We also demonstrate that HDAC4 and Ubc9 interact genetically during memory formation, opening new avenues for investigating the mechanisms through which HDAC4 regulates memory formation and other neurological processes.
Title: Long-Term Memory in Drosophila Is Influenced by Histone Deacetylase HDAC4 Interacting with SUMO-Conjugating Enzyme Ubc9.
dUbc9 contributes to the regulation of both humoral immunity and hemocyte proliferation by acting as a negative regulator of the Toll pathway.
Title: dUbc9 negatively regulates the Toll-NF-kappa B pathways in larval hematopoiesis and drosomycin activation in Drosophila.
lesswright mutation activates Rel-related proteins, leading to overproduction of larval hemocytes in Drosophila melanogaster
Title: The lesswright mutation activates Rel-related proteins, leading to overproduction of larval hemocytes in Drosophila melanogaster.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Dm0628 (e-PCR)
- UniSTS:6840

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables SUMO conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables SUMO conjugating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables SUMO conjugating enzyme activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables heat shock protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin activating enzyme binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to transforming growth factor beta stimulus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female meiosis chromosome segregation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in female meiotic nuclear division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation melanotic encapsulation of foreign target	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Toll signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Toll signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hemocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hemocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lamellocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antimicrobial peptide production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of somatic stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein modification process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein sumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein sumoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein sumoylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in spectrosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transposable element silencing by piRNA-mediated heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of outer kinetochore	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: lesswright

Names: CG3018-PA; CG3018-PB; CG3018-PC; CG3018-PD; hunchback-like; leswright; lwr-PA; lwr-PB; lwr-PC; lwr-PD; semushi; ubiquitin conjugating enzyme 9; ubiquitin-conjugating enzyme 9