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    bumpel brother of rumpel [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41368, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bumpelprovided by FlyBase
    Official Full Name
    brother of rumpelprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037895
    Locus tag
    Dmel_CG6723
    See related
    AllianceGenome:FB:FBgn0037895
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6723; Dmel\CG6723; dSLC5A8
    Summary
    Enables solute:sodium symporter activity. Involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head; embryonic brain; larval nervous system; larval ventral nerve cord; and lateral cord. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A12 (solute carrier family 5 member 12); SLC5A5 (solute carrier family 5 member 5); and SLC5A8 (solute carrier family 5 member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See bumpel in Genome Data Viewer
    Location:
    86E4-86E5; 3-51 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11416218..11418668, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7241940..7244390, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Inverted repeat-binding protein Neighboring gene Importin 9 Neighboring gene uncharacterized protein Neighboring gene ninaG

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Social reprogramming in ants induces longevity-associated glia remodeling. Sheng L, et al. Sci Adv, 2020 Aug. PMID 32875108, Free PMC Article
    2. A monocarboxylate transporter rescues frontotemporal dementia and Alzheimer's disease models. Xu D, et al. PLoS Genet, 2023 Sep. PMID 37733679, Free PMC Article
    3. Redundant functions of the SLC5A transporters Rumpel, Bumpel, and Kumpel in ensheathing glial cells. Yildirim K, et al. Biol Open, 2022 Jan 15. PMID 34897385, Free PMC Article
    4. A novel post-developmental role of the Hox genes underlies normal adult behavior. Raouf Issa A, et al. Proc Natl Acad Sci U S A, 2022 Dec 6. PMID 36454751, Free PMC Article
    5. Taste-independent nutrient selection is mediated by a brain-specific Na+ /solute co-transporter in Drosophila. Dus M, et al. Nat Neurosci, 2013 May. PMID 23542692, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables solute:sodium symporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    brother of rumpel
    Names
    CG6723-PA
    bumpel-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11416218..11418668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141812.3 → NP_650069.2  brother of rumpel [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650069.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXL4, Q9VGP3
      Related
      FBpp0081881
      Conserved Domains (1) summary
      cd11492
      Location:17 → 537
      SLC5sbd_NIS-SMVT; Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXL4 Q8SXL4
    Q9VGP3 Q9VGP3

    Gene LinkOut

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