Pph13 PvuII-PstI homology 13 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pph13provided by FlyBase
Official Full Name: PvuII-PstI homology 13provided by FlyBase
Primary source: FLYBASE:FBgn0023489
Locus tag: Dmel_CG2819
See related: AllianceGenome:FB:FBgn0023489
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 60Mun1; CG2819; Dmel\CG2819; hazy; Mu; pph13; PPH13
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in ocellus photoreceptor cell development; positive regulation of transcription by RNA polymerase II; and rhabdomere development. Located in nucleus. Is expressed in Bolwig organ primordium; photoreceptor; photoreceptor neurons; retina; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in several diseases, including frontonasal dysplasia 1; frontonasal dysplasia 2; frontonasal dysplasia 3; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human ALX1 (ALX homeobox 1); ALX3 (ALX homeobox 3); and ALX4 (ALX homeobox 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 21E2-21E2; 2-1.5 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (577486..579549)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (577486..579549)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Authors conclude that Glass can either directly or indirectly initiate the expression of most phototransduction proteins in a Hazy-independent manner, and that Hazy is mainly required for the maintenance of functional photoreceptors in adult flies.
Title: Successive requirement of Glass and Hazy for photoreceptor specification and maintenance in Drosophila.
Although Otd and Pph13 have been implicated in rhabdomere morphogenesis, we demonstrate that it is necessary to remove both factors to completely eliminate rhabdomere formation.
Title: Pph13 and orthodenticle define a dual regulatory pathway for photoreceptor cell morphogenesis and function.
Data show that Pph13 is required for both rhabdomere morphogenesis and for the proper detection of light.
Title: Mutation of the photoreceptor specific homeodomain gene Pph13 results in defects in phototransduction and rhabdomere morphogenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in compound eye photoreceptor development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ocellus photoreceptor cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in photoreceptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in rhabdomere development	IMP Inferred from Mutant Phenotype more info	PubMed