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    dachs dachs [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34179, updated on 17-Dec-2024

    Summary

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    Official Symbol
    dachsprovided by FlyBase
    Official Full Name
    dachsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262029
    Locus tag
    Dmel_CG42840
    See related
    AllianceGenome:FB:FBgn0262029
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    29C3-D1; 29CD; AAF52683; anon-EST:Liang-1.78; CG10595; CG13087; CG31610; CG42840; clone 1.78; d; D; Dachs; Dh; Dmel\CG42840; DmMyo20; Ds; l(2)c00146; Myo29D; Myo3A
    Old locus tag
    Dmel_CG10595; Dmel_CG13087
    Summary
    Enables actin filament binding activity and molecular adaptor activity. Involved in several processes, including establishment of planar polarity; imaginal disc-derived wing vein morphogenesis; and negative regulation of hippo signaling. Located in apicolateral plasma membrane and cytosol. Is expressed in several structures, including dorsal epidermis primordium; embryonic dorsal epidermis; embryonic head epidermis; gut section; and head epidermis primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dachs in Genome Data Viewer
    Location:
    29D1-29D1; 2-33 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8466817..8488671)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8466817..8488671)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene 1-Acylglycerol-3-phosphate O-acyltransferase 2 Neighboring gene piragua Neighboring gene transfer RNA:Aspartic acid-GTC 1-2 Neighboring gene transfer RNA:Aspartic acid-GTC 1-3 Neighboring gene Chemosensory protein A 29a Neighboring gene long non-coding RNA:CR43604 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pattern as a function of cell number and cell size on the second-leg basitarsus ofDrosophila. Held LI Jr. Wilehm Roux Arch Dev Biol, 1979 Jun. PMID 28304925
    2. Prickle isoforms control the direction of tissue polarity by microtubule independent and dependent mechanisms. Sharp KA, et al. Biol Open, 2016 Feb 10. PMID 26863941, Free PMC Article
    3. Drosophila myosin-XX functions as an actin-binding protein to facilitate the interaction between Zyx102 and actin. Cao Y, et al. Biochemistry, 2014 Jan 21. PMID 24393048
    4. A global pattern of mechanical stress polarizes cell divisions and cell shape in the growing Drosophila wing disc. Legoff L, et al. Development, 2013 Oct. PMID 24046320
    5. The Dachsous/Fat/Four-Jointed Pathway Directs the Uniform Axial Orientation of Epithelial Cells in the Drosophila Abdomen. Mangione F, et al. Cell Rep, 2018 Dec 4. PMID 30517870

    See all (149) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Boundaries of Ft and Ds expression result in subcellular asymmetries in protein distribution that are transmitted to neighboring cells, and asymmetric Ds localization results in a corresponding asymmetric distribution of the myosin Dachs.
      Title: Planar polarity specification through asymmetric subcellular localization of Fat and Dachsous.
    2. role in signaling interactions that regulate growth and patterning of the proximal wing; Dachs is a candidate downstream effector of a Fat signaling pathway
      Title: Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling.
    3. Dachs is a crucial downstream component of a Fat signaling pathway that influences growth, affinity and gene expression during development.
      Title: Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables cytoskeletal motor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of ommatidial planar polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of planar polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in leg disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of imaginal disc growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization involved in establishment of planar polarity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apicolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dachs
    Names
    CG42840-PD
    CG42840-PE
    dachs-PD
    dachs-PE
    lethal (2) c00146
    myosin 29D
    unconventional myosin 29D

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8466817..8488671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201801.2 → NP_001188730.1  dachs, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRE4, Q95VU9
      Conserved Domains (2) summary
      smart00242
      Location:476 → 1217
      MYSc; Myosin. Large ATPases
      cd14881
      Location:488 → 1206
      MYSc_Myo20; class XX myosin, motor domain

    2. NM_001201800.1 → NP_001188729.1  dachs, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJR1, Q95VU9
      Conserved Domains (2) summary
      smart00242
      Location:294 → 1035
      MYSc; Myosin. Large ATPases
      cd14881
      Location:306 → 1024
      MYSc_Myo20; class XX myosin, motor domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B5RJR1 B5RJR1
    M9MRE4 M9MRE4
    Q8T6L8 Q8T6L8
    Q8T6L9 Q8T6L9
    Q95VU9 Q95VU9
    Q960K4 Q960K4

    Gene LinkOut

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