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    Spn Spinophilin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46194, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Spnprovided by FlyBase
    Official Full Name
    Spinophilinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010905
    Locus tag
    Dmel_CG16757
    See related
    AllianceGenome:FB:FBgn0010905
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM16129; c62E-5; CG16757; Dmel\CG16757; E62; EL62; l(3)06911; spn
    Summary
    Enables neurexin family protein binding activity. Involved in negative regulation of presynaptic active zone assembly. Located in apical cortex. Colocalizes with contractile ring. Is expressed in adult brain; adult head; adult heart; spermatozoon; and synaptic neuropil domain. Orthologous to human PPP1R9A (protein phosphatase 1 regulatory subunit 9A) and PPP1R9B (protein phosphatase 1 regulatory subunit 9B). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See Spn in Genome Data Viewer
    Location:
    62E4-62E5; 3-3 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2505245..2554292, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2505245..2554292, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45425 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45170 Neighboring gene uncharacterized protein Neighboring gene misshapen Neighboring gene Ribosomal protein L8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity. Ramesh N, et al. Elife, 2023 Sep 28. PMID 37767892, Free PMC Article
    2. Gene dosage and selective expression modify phenotype in a Drosophila model of human mitochondrial disease. Toivonen JM, et al. Mitochondrion, 2003 Oct. PMID 16120347
    3. The 62E early-late puff of Drosophila contains D-spinophilin, an ecdysone-inducible PDZ-domain protein dynamically expressed during metamorphosis. Keegan J, et al. Genet Res, 2001 Feb. PMID 11279828
    4. Transmission of the wMel Wolbachia strain is modulated by its titre and by immune genes in Drosophila melanogaster (Wolbachia density and transmission). Liu XC, et al. J Invertebr Pathol, 2021 May. PMID 33882275
    5. Lead exposure induced transgenerational developmental neurotoxicity by altering genome methylation in Drosophila melanogaster. Wu C, et al. Ecotoxicol Environ Saf, 2024 Feb. PMID 38237395

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. presynaptic spinophilin fine-tunes neurexin/neuroligin signalling to control active zone number and functionality
      Title: Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neurexin family protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of presynaptic active zone assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical cortex HDA PubMed 
    colocalizes_with contractile ring HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    spinophilin
    Names
    CG16757-PB
    CG16757-PC
    CG16757-PD
    CG16757-PE
    CG16757-PF
    CG16757-PG
    CG16757-PH
    CG16757-PI
    CG16757-PJ
    CG16757-PS
    CG16757-PT
    SPINOPHILIN
    Spn-PB
    Spn-PC
    Spn-PD
    Spn-PE
    Spn-PF
    Spn-PG
    Spn-PH
    Spn-PI
    Spn-PJ
    Spn-PS
    Spn-PT
    d-spinophilin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2505245..2554292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259642.1 → NP_001246571.1  spinophilin, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1Z359, M9NEY3
      Conserved Domains (4) summary
      cd09512
      Location:2036 → 2104
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      smart00454
      Location:2039 → 2103
      SAM; Sterile alpha motif
      smart00228
      Location:1262 → 1347
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cl21524
      Location:1417 → 1519
      PRK13923; putative spore coat protein regulator protein YlbO; Provisional

    2. NM_001259647.1 → NP_001246576.1  spinophilin, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1Z359, M9NEY3
      Conserved Domains (4) summary
      cd09512
      Location:2036 → 2104
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      smart00454
      Location:2039 → 2103
      SAM; Sterile alpha motif
      smart00228
      Location:1262 → 1347
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cl21524
      Location:1417 → 1519
      PRK13923; putative spore coat protein regulator protein YlbO; Provisional

    3. NM_001259648.1 → NP_001246577.1  spinophilin, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1Z359, M9NDX8
      Conserved Domains (4) summary
      cd09512
      Location:2018 → 2086
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      smart00454
      Location:2021 → 2085
      SAM; Sterile alpha motif
      smart00228
      Location:1262 → 1347
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam14662
      Location:1375 → 1545
      KASH_CCD; Coiled-coil region of CCDC155 or KASH

    4. NM_001259646.1 → NP_001246575.1  spinophilin, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1Z359, M9NEY5
      Conserved Domains (4) summary
      cd09512
      Location:2023 → 2091
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      smart00454
      Location:2026 → 2090
      SAM; Sterile alpha motif
      smart00228
      Location:1255 → 1340
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cl21524
      Location:1410 → 1512
      PRK13923; putative spore coat protein regulator protein YlbO; Provisional

    5. NM_001259644.1 → NP_001246573.1  spinophilin, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1Z359, M9NFI2
      Conserved Domains (4) summary
      cd09512
      Location:1719 → 1787
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      smart00454
      Location:1722 → 1786
      SAM; Sterile alpha motif
      smart00228
      Location:1262 → 1347
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cl21524
      Location:1417 → 1519
      PRK13923; putative spore coat protein regulator protein YlbO; Provisional

    6. NM_001299992.1 → NP_001286921.1  spinophilin, isoform T [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1Z359, X2JC06
      Conserved Domains (4) summary
      cd09512
      Location:1733 → 1801
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      smart00454
      Location:1736 → 1800
      SAM; Sterile alpha motif
      smart00228
      Location:1262 → 1347
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cl21524
      Location:1417 → 1519
      PRK13923; putative spore coat protein regulator protein YlbO; Provisional

    7. NM_001259645.1 → NP_001246574.1  spinophilin, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9ND28
      Conserved Domains (2) summary
      smart00228
      Location:1262 → 1347
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cl21524
      Location:1417 → 1519
      PRK13923; putative spore coat protein regulator protein YlbO; Provisional

    8. NM_001259641.1 → NP_001246570.1  spinophilin, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1Z359, M9NEY3
      Conserved Domains (4) summary
      cd09512
      Location:2036 → 2104
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      smart00454
      Location:2039 → 2103
      SAM; Sterile alpha motif
      smart00228
      Location:1262 → 1347
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cl21524
      Location:1417 → 1519
      PRK13923; putative spore coat protein regulator protein YlbO; Provisional

    9. NM_001259649.1 → NP_001246578.1  spinophilin, isoform J [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1Z359, M9NFI9
      Conserved Domains (4) summary
      cd09512
      Location:2050 → 2118
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      smart00454
      Location:2053 → 2117
      SAM; Sterile alpha motif
      smart00228
      Location:1262 → 1347
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cl21524
      Location:1417 → 1519
      PRK13923; putative spore coat protein regulator protein YlbO; Provisional

    10. NM_080516.3 → NP_536777.3  spinophilin, isoform S [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1Z359, Q9W003
      Conserved Domains (4) summary
      cd09512
      Location:2021 → 2089
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      smart00454
      Location:2024 → 2088
      SAM; Sterile alpha motif
      smart00228
      Location:1262 → 1347
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam14662
      Location:1375 → 1548
      KASH_CCD; Coiled-coil region of CCDC155 or KASH

    11. NM_001259643.1 → NP_001246572.1  spinophilin, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1Z359, H5V864
      Conserved Domains (4) summary
      cd09512
      Location:2039 → 2107
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      smart00454
      Location:2042 → 2106
      SAM; Sterile alpha motif
      smart00228
      Location:1262 → 1347
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cl21524
      Location:1420 → 1522
      PRK13923; putative spore coat protein regulator protein YlbO; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H5V864 H5V864
    M9ND28 M9ND28
    M9NDX8 M9NDX8
    M9NEY3 M9NEY3
    M9NEY5 M9NEY5
    M9NFI2 M9NFI2
    M9NFI9 M9NFI9
    Q8MSF6 Q8MSF6
    Q8MSU5 Q8MSU5
    Q9GQA3 Q9GQA3
    Q9W003 Q9W003
    X2JC06 X2JC06

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