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    scramb2 scramblase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38362, updated on 9-Dec-2024

    Summary

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    Official Symbol
    scramb2provided by FlyBase
    Official Full Name
    scramblase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0035390
    Locus tag
    Dmel_CG1893
    See related
    AllianceGenome:FB:FBgn0035390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1893; Dmel\CG1893; Scramb2
    Summary
    Predicted to enable phospholipid scramblase activity. Involved in chemical synaptic transmission. Predicted to be active in plasma membrane. Is expressed in several structures, including adult heart; anterior-posterior subdivision of organism; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to several human genes including PLSCR1 (phospholipid scramblase 1); PLSCR2 (phospholipid scramblase 2); and PLSCR5 (phospholipid scramblase family member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See scramb2 in Genome Data Viewer
    Location:
    63A3-63A3; 3-5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3044113..3046812, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3044113..3046812, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene always early Neighboring gene uncharacterized protein Neighboring gene Peroxiredoxin 4 Neighboring gene Sphingosine kinase 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A gene expression map for the euchromatic genome of Drosophila melanogaster. Stolc V, et al. Science, 2004 Oct 22. PMID 15499012
    2. Drosophila melanogaster Scramblases modulate synaptic transmission. Acharya U, et al. J Cell Biol, 2006 Apr 10. PMID 16606691, Free PMC Article
    3. Phospholipid scramblase 1: an essential component of the nephrocyte slit diaphragm. Castillo-Mancho V, et al. Cell Mol Life Sci, 2024 Jun 15. PMID 38878170, Free PMC Article
    4. The coagulation of insect hemolymph. Theopold U, et al. Cell Mol Life Sci, 2002 Feb. PMID 11915949, Free PMC Article
    5. A screen of apoptosis and senescence regulatory genes for life span effects when over-expressed in Drosophila. Shen J, et al. Aging (Albany NY), 2009 Jan 30. PMID 20157509, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phospholipid scramblase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid scramblase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid scramblase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasma membrane phospholipid scrambling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane phospholipid scrambling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    scramblase 2
    Names
    CG1893-PA
    scramb2-PA
    scramblase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3044113..3046812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139504.3 → NP_647761.1  scramblase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647761.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZW1
      Related
      FBpp0072875
      Conserved Domains (1) summary
      pfam03803
      Location:42 → 263
      Scramblase; Scramblase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZE1 Q8SZE1
    Q9VZW1 Q9VZW1

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