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    mthl15 methuselah-like 15 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318914, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mthl15provided by FlyBase
    Official Full Name
    methuselah-like 15provided by FlyBase
    Primary source
    FLYBASE:FBgn0051720
    Locus tag
    Dmel_CG31720
    See related
    AllianceGenome:FB:FBgn0051720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31720; Dmel\CG31720
    Summary
    Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mthl15 in Genome Data Viewer
    Location:
    31B1-31B1; 2-40 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10234585..10238317, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10234585..10238317, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene ovaries absent Neighboring gene eukaryotic translation elongation factor 1 delta Neighboring gene maternal expression at 31B Neighboring gene antisense RNA:CR44995 Neighboring gene chico

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila mojavensis - chico. Congleton H, et al. MicroPubl Biol, 2022. PMID 36468157, Free PMC Article
    2. Transcriptomic and functional genetic evidence for distinct ecophysiological responses across complex life cycle stages. Freda PJ, et al. J Exp Biol, 2022 Jun 1. PMID 35578907
    3. Methuselah/Methuselah-like G protein-coupled receptors constitute an ancient metazoan gene family. de Mendoza A, et al. Sci Rep, 2016 Feb 26. PMID 26915348, Free PMC Article
    4. Gene Ages, Nomenclatures, and Functional Diversification of the Methuselah/Methuselah-Like GPCR Family in Drosophila and Tribolium. Friedrich M, et al. J Exp Zool B Mol Dev Evol, 2016 Dec. PMID 28074535
    5. Genetic variation in the shape of cold-survival curves in a single fly population suggests potential for selection from climate variability. Teets NM, et al. J Evol Biol, 2018 Apr. PMID 29345010

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    methuselah-like 15
    Names
    CG31720-PC
    CG31720-PD
    mthl15-PC
    mthl15-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10234585..10238317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164897.3 → NP_723538.3  methuselah-like 15, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723538.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2QCS3
      Conserved Domains (2) summary
      cl11637
      Location:247 → 355
      Mth_Ecto; The ectodomain of Methuselah (Mth); Mth mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage; The protein affected by this mutation is related to G ...
      cl21561
      Location:385 → 646
      7tm_4; Olfactory receptor

    2. NM_164896.2 → NP_723537.2  methuselah-like 15, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723537.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPD1
      Conserved Domains (1) summary
      cl11637
      Location:247 → 355
      Mth_Ecto; The ectodomain of Methuselah (Mth); Mth mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage; The protein affected by this mutation is related to G ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E2QCS3 E2QCS3
    Q8IPD1 Q8IPD1

    Gene LinkOut

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